Zhao Miaomiao, Wang Songpo, Li Qi, Ji Qing, Guo Piaoting, Liu Xiaowei
Department of Traditional Chinese Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, P.R. China.
Department of Oncology, Zhengzhou Traditional Chinese Medicine Hospital, Zhengzhou 450007, P.R. China.
Oncol Lett. 2018 Jul;16(1):19-26. doi: 10.3892/ol.2018.8613. Epub 2018 May 2.
Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1), a well-known lncRNA associated with numerous diseases, particularly cancer, has received increased attention. The expression of MALAT1 was determined to be upregulated in numerous types of tumors and MALAT1 exhibited effects on tumor cell proliferation, migration, invasion and apoptosis. The abnormal expression of MALAT1 was identified in almost in every organ of the digestive system. MALAT1 performed an important role in the pathological alterations of organs that are associated with sex hormones and several reproductive system cancers. MALAT1 participates in molecular pathways. In the clinical application of MALAT1, MALAT1 was considered as a potential biomarker for the diagnosis and prediction of cancers, and may also serve as therapeutic target for treatment of specific tumors. This review summarizes the abnormal expression of MALAT1 in cancer, its significant effect on the primary features of cancer, as well as the underlying molecular mechanisms of MALAT1 in various cancers. According to studies on MALAT1, we introduce the upstream and downstream substances associated with the function of MALAT1. These reviewed studies promote the clinical application of MALAT1 in the aspect of diagnosis and treatment of different cancers, and may help point out new study directions for MALAT1.
转移相关的肺腺癌转录本1（MALAT1）是一种与多种疾病尤其是癌症相关的著名长链非编码RNA，已受到越来越多的关注。研究确定MALAT1在多种肿瘤类型中表达上调，并且MALAT1对肿瘤细胞的增殖、迁移、侵袭和凋亡均有影响。几乎在消化系统的每个器官中都发现了MALAT1的异常表达。MALAT1在与性激素相关的器官病理改变以及几种生殖系统癌症中发挥重要作用。MALAT1参与分子通路。在MALAT1的临床应用中，它被认为是癌症诊断和预测的潜在生物标志物，也可能作为特定肿瘤治疗的靶点。本文综述了MALAT1在癌症中的异常表达、其对癌症主要特征的显著影响以及MALAT1在各种癌症中的潜在分子机制。根据对MALAT1的研究，我们介绍了与MALAT1功能相关的上下游物质。这些综述性研究促进了MALAT1在不同癌症诊断和治疗方面的临床应用，并可能有助于为MALAT1指出新的研究方向。
