Kirk Peter S, Borza Tudor, Dupree James M, Wei John T, Ellimoottil Chad, Caram Megan E V, Burkhardt Mary, Heidelbaugh Joel J, Hollenbeck Brent K, Skolarus Ted A
Dow Division of Health Services Research, Department of Urology, VA Ann Arbor Healthcare System, Ann Arbor, Michigan.
Division of Hematology & Oncology, Department of Internal Medicine, VA Ann Arbor Healthcare System, Ann Arbor, Michigan.
Urol Pract. 2018 Sep;5(5):351-359. doi: 10.1016/j.urpr.2017.07.004.
Millions of patients take prescription medications each year for common urological conditions. Generic and brand-name drugs have widely divergent pricing despite similar therapeutic benefit and side effect profiles. We examined prescribing patterns across provider types for generic and brand-name drugs used to treat 3 common urological conditions, and estimated economic implications for Medicare Part D spending.
We extracted 2014 prescription claims and payments from Medicare Part D and categorized oral medications used to treat 3 urological conditions, namely benign prostatic hyperplasia, erectile dysfunction and overactive bladder. We examined claims and payments for each medication among urologists and nonurologists. Lastly, we estimated potential savings by selecting a low cost or generic drug as a cost comparator for each class.
There were significant differences in prescribing patterns across these conditions, with urologists prescribing more brand-name and expensive medications (p <0.001). The total potential savings related to prescriptions of more expensive and nongeneric drugs in 2014 was $1 billion (benign prostatic hyperplasia $348,454,910, erectile dysfunction $10,211,914 and overactive bladder $698,130,833). These potential savings comprised 53% of the total spending for these medications in 2014.
Within Medicare Part D the potential savings associated with generic substitution for higher cost and nongeneric drugs for 3 common urological conditions surpassed $1 billion, with urologists more likely to prescribe brand-name and more expensive drugs. Increasing low cost and generic drug use where available evidence of efficacy is equivocal represents a promising policy target to optimize prescription drug spending.
每年有数百万患者因常见的泌尿系统疾病而服用处方药。尽管通用名药物和品牌名药物在治疗益处和副作用方面相似,但它们的定价却大相径庭。我们研究了用于治疗三种常见泌尿系统疾病的通用名药物和品牌名药物在不同医疗服务提供者类型中的处方模式,并估计了对医疗保险D部分支出的经济影响。
我们从医疗保险D部分提取了2014年的处方索赔和支付信息,并对用于治疗三种泌尿系统疾病(即良性前列腺增生、勃起功能障碍和膀胱过度活动症)的口服药物进行了分类。我们研究了泌尿科医生和非泌尿科医生对每种药物的索赔和支付情况。最后,我们选择低成本或通用名药物作为每类药物的成本比较对象,估计了潜在的节省费用。
这些疾病的处方模式存在显著差异,泌尿科医生开出的品牌名药物和昂贵药物更多(p<0.001)。2014年,与更昂贵的非通用名药物处方相关的潜在节省费用为10亿美元(良性前列腺增生348454910美元,勃起功能障碍10211914美元,膀胱过度活动症698130833美元)。这些潜在节省费用占2014年这些药物总支出的53%。
在医疗保险D部分,对于三种常见泌尿系统疾病,用通用名药物替代高成本和非通用名药物的潜在节省费用超过10亿美元,泌尿科医生更倾向于开出品牌名和更昂贵的药物。在疗效证据不明确的情况下增加低成本和通用名药物的使用,是优化处方药支出的一个有前景的政策目标。