Yang Charles Q, Mathur Anisha, Kumar Princy N, Dhillon Vaninder K
1 Department of Otolaryngology, Walter Reed National Military Medical Center, Bethesda, MD, USA.
2 Departmant of Infectious Disease, Medstar Georgetown University Hospital, Washington, DC, USA.
Ann Otol Rhinol Laryngol. 2019 Mar;128(3):267-270. doi: 10.1177/0003489418818579. Epub 2018 Dec 17.
: Laryngopharyngeal herpes simplex virus infection is rare and presents typically in the supraglottis. Findings on presentation can range from small mucosal lesions to fungating obstructive masses mimicking neoplasm. Laryngopharyngeal herpes is a medically treated disease.
: Identify potential treatment in cases that are refractory to antiviral medications.
: Individual case with treatment adapted from other case report.
: We report a case of bulky, obstructive supraglottic and glottic herpes virus laryngitis that presented with dysphonia, dysphagia, and airway complaints resistant to acyclovir analogues that was treated effectively with intralesional cidofovir injection.
: Our promising initial response suggests a potential novel treatment for this unusual condition.
喉咽单纯疱疹病毒感染较为罕见，通常出现在声门上区。临床表现多样，从小的黏膜病变到类似肿瘤的溃疡性阻塞性肿块不等。喉咽疱疹是一种可通过药物治疗的疾病。
确定对抗病毒药物难治的病例的潜在治疗方法。
根据其他病例报告对个体病例进行治疗。
我们报告一例巨大的、阻塞性声门上和声门疱疹病毒性喉炎病例，患者出现声音嘶哑、吞咽困难和气道问题，对阿昔洛韦类似物治疗无效，经病灶内注射西多福韦有效治疗。
我们令人鼓舞的初步反应表明，这种特殊情况可能有新的治疗方法。
