Yeh V, Hopp M L, Goldstein N S, Meyer R D
Department of Medicine, Cedars-Sinai Medical Center, Cedars-Sinai Research Institute, Los Angeles, California.
Ann Otol Rhinol Laryngol. 1994 Sep;103(9):726-31. doi: 10.1177/000348949410300912.
Chronic laryngitis in patients with acquired immunodeficiency syndrome may be due to infections or tumors, such as Kaposi's sarcoma and non-Hodgkin's lymphoma. We present what we believe to be the first proven case of herpes simplex virus chronic laryngitis in a man positive for human immunodeficiency virus. Direct laryngoscopy showed leukoplakic lesions on both vocal cords. Biopsy of the lesions showed squamous epithelial cells with the characteristic features of herpes simplex virus, which was confirmed by immunohistochemical stains. We discuss the differential diagnosis of chronic laryngitis in a human immunodeficiency virus infection. Herpes simplex viral infection of the vocal cords should be considered in patients with acquired immunodeficiency syndrome presenting with chronic hoarseness and leukoplakic lesions on direct laryngoscopy, especially with no evidence of Kaposi's sarcoma, tumor, or cytomegaloviral or fungal infection elsewhere. Treatment should be acyclovir, except in the face of acyclovir resistance.
获得性免疫缺陷综合征患者的慢性喉炎可能由感染或肿瘤引起，如卡波西肉瘤和非霍奇金淋巴瘤。我们报告了我们认为是首例经证实的人类免疫缺陷病毒阳性男性单纯疱疹病毒慢性喉炎病例。直接喉镜检查显示双侧声带出现白斑样病变。病变活检显示鳞状上皮细胞具有单纯疱疹病毒的特征性表现，免疫组化染色证实了这一点。我们讨论了人类免疫缺陷病毒感染中慢性喉炎的鉴别诊断。对于出现慢性声音嘶哑且直接喉镜检查有白斑样病变的获得性免疫缺陷综合征患者，尤其是在其他部位没有卡波西肉瘤、肿瘤、巨细胞病毒或真菌感染证据的情况下，应考虑声带的单纯疱疹病毒感染。除了对阿昔洛韦耐药的情况外，治疗应使用阿昔洛韦。
