子宫内膜癌中的性类固醇受体。
Sex steroid receptors in endometrial cancer.
作者信息
Chambers J T
机构信息
Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, CT 06510.
出版信息
Yale J Biol Med. 1988 Jul-Aug;61(4):339-50.
Endometrial cancer contains estrogen and progestin receptor proteins. The receptor content inversely correlates with histologic differentiation. The correlation between receptor content and histologic subtype and stage of the disease may depend upon the degree of differentiation of the tumor. The status of the peritoneal cytology and depth of myometrial invasion by tumor do not correlate with the receptor status. In general, patients with receptor-rich tumors have a better prognosis than those without receptors and respond favorably to progestin therapy. The level of the receptor protein in the tumor may also influence survival.
子宫内膜癌含有雌激素和孕激素受体蛋白。受体含量与组织学分化呈负相关。受体含量与疾病的组织学亚型和分期之间的相关性可能取决于肿瘤的分化程度。腹膜细胞学状态和肿瘤肌层浸润深度与受体状态无关。一般来说，肿瘤富含受体的患者比没有受体的患者预后更好，并且对孕激素治疗反应良好。肿瘤中受体蛋白的水平也可能影响生存。
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