Alcoverro Emili, Bersan Erika, Sanchez-Masian Daniel, Piviani Martina
Department of Small Animal Clinical Science, Institute of Veterinary Science, University of Liverpool, Neston, UK.
Vet Clin Pathol. 2019 Mar;48(1):78-82. doi: 10.1111/vcp.12684. Epub 2018 Dec 17.
A 1-year-old, female intact Pug dog was presented to the Small Animal Teaching Hospital of the University of Liverpool with a 4-week history of progressive multifocal intracranial signs. Magnetic resonance imaging (MRI) detected multiple hemorrhagic lesions in the brain. The Baermann and zinc sulfate flotation tests with centrifugation, performed on fecal samples, were positive for lungworm larvae and an antigenic test confirmed Angiostrongylus vasorum infection. Anthelmintic treatment was started with a consequent marked clinical improvement. Seventy days later, the dog was clinically normal, and no larvae were detected on the Baermann test. Repeat MRI of the brain revealed marked improvement of the hemorrhagic lesions. Cerebrospinal fluid analysis (CSF) showed marked eosinophilic pleocytosis, and anthelmintic treatment was restarted. A follow-up CSF analysis 4 months after the first presentation revealed resolution of the eosinophilic pleocytosis. This is the first case report of marked eosinophilic pleocytosis associated with neural A vasorum infection in a dog. The CSF eosinophilic pleocytosis persisted for several weeks after treatment, even in the absence of concurrent clinical signs and with a negative A vasorum Baermann test.
一只1岁的未绝育雌性哈巴狗被送到利物浦大学小动物教学医院，有4周渐进性多灶性颅内症状病史。磁共振成像（MRI）检测到脑部有多个出血性病变。对粪便样本进行的贝尔曼法和硫酸锌离心漂浮试验显示肺线虫幼虫呈阳性，抗原检测确诊为血管圆线虫感染。开始进行驱虫治疗后临床症状明显改善。70天后，这只狗临床症状正常，贝尔曼试验未检测到幼虫。脑部重复MRI显示出血性病变明显改善。脑脊液分析（CSF）显示明显的嗜酸性粒细胞增多，于是重新开始驱虫治疗。首次就诊4个月后的随访脑脊液分析显示嗜酸性粒细胞增多症已消退。这是第一例关于狗神经血管圆线虫感染相关明显嗜酸性粒细胞增多症的病例报告。即使在没有并发临床症状且血管圆线虫贝尔曼试验呈阴性的情况下，治疗后脑脊液嗜酸性粒细胞增多症仍持续了数周。
