Department of Clinical Sciences and Advanced Medicine, University of Pennsylvania School of Veterinary Medicine, Philadelphia, Pennsylvania, USA.
Department of Surgical and Radiological Sciences, University of California School of Veterinary Medicine, Davis, California, USA.
J Vet Intern Med. 2023 Nov-Dec;37(6):2492-2497. doi: 10.1111/jvim.16854. Epub 2023 Oct 17.
A 3-year-old male pit bull terrier was presented for a 4-day history of progressive tetraparesis and cervical pain. Magnetic resonance imaging confirmed an extradural mass within the left lateral vertebral canal extending from caudal C5 to mid-T2. Lumbar cerebrospinal fluid (CSF) demonstrated marked (90%) eosinophilic inflammation. A C6-7 dorsal laminectomy and C7-T2 left hemilaminectomy were done, with gross disease remaining. Histopathology revealed a large T cell lymphoma with marked eosinophilic infiltration. The dog underwent CHOP-based chemotherapy with resolution of clinical signs, with a similar course of therapy performed at recurrence 37 months after initial presentation. The dog was euthanized 39 months after presentation for multiorgan failure secondary to neutropenic sepsis and aspiration pneumonia. This represents a positive long-term response to multimodal treatment of extradural T-cell lymphoma within the vertebral canal associated with a marked CSF eosinophilia.
一只 3 岁雄性比特斗牛梗因进行性四肢瘫痪和颈部疼痛就诊，病史 4 天。磁共振成像（MRI）证实左侧外侧椎管内有硬膜外肿块，从 C5 尾侧向 T2 中段延伸。腰椎脑脊液（CSF）显示明显（90%）嗜酸性粒细胞炎症。进行 C6-7 背侧椎板切除术和 C7-T2 左侧半椎板切除术，但仍有肉眼可见的病变。组织病理学显示大 T 细胞淋巴瘤伴明显嗜酸性粒细胞浸润。该犬接受基于 CHOP 的化疗后临床症状缓解，初次就诊后 37 个月复发时再次进行类似疗程的治疗。该犬在初次就诊后 39 个月因中性粒细胞减少性脓毒症和吸入性肺炎继发多器官衰竭而安乐死。这代表了对椎管内硬膜外 T 细胞淋巴瘤的多模式治疗的积极长期反应，与 CSF 嗜酸性粒细胞增多有关。
