Department of Science in Korean Medicine, Kyung Hee University, 24 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Korea.
Comorbidity Research Institute, College of Korean Medicine, Kyung Hee University, 24 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Korea.
Int J Mol Sci. 2018 Dec 14;19(12):4048. doi: 10.3390/ijms19124048.
Cancer still remains one of the leading causes of death worldwide. In spite of significant advances in treatment options and the advent of novel targeted therapies, there still remains an unmet need for the identification of novel pharmacological agents for cancer therapy. This has led to several studies evaluating the possible application of natural agents found in vegetables, fruits, or plant-derived products that may be useful for cancer treatment. Bergamottin is a furanocoumarin derived from grapefruits and is also a well-known cytochrome P450 inhibitor. Recent studies have demonstrated potent anti-oxidative, anti-inflammatory, and anti-cancer properties of grapefruit furanocoumarin both in vitro and in vivo. The present review focuses on the potential anti-neoplastic effects of bergamottin in different tumor models and briefly describes the molecular targets affected by this agent.
癌症仍然是全球主要的死亡原因之一。尽管在治疗选择和新型靶向治疗方面取得了重大进展，但仍需要确定新的用于癌症治疗的药理学药物。这导致了几项研究评估了在蔬菜、水果或植物衍生产品中发现的天然物质的可能应用，这些物质可能对癌症治疗有用。佛手柑素是一种来源于葡萄柚的呋喃香豆素，也是一种众所周知的细胞色素 P450 抑制剂。最近的研究表明，葡萄柚呋喃香豆素具有强大的抗氧化、抗炎和抗癌特性，无论是在体外还是体内。本综述重点介绍了佛手柑素在不同肿瘤模型中的潜在抗肿瘤作用，并简要描述了该药物影响的分子靶点。
