Department of Physiology, (Cellular Physiology Research Group), Institute of Molecular Pathology Biomarkers, University of Extremadura, 10003 Caceres, Spain.
Int J Mol Sci. 2018 Dec 14;19(12):4053. doi: 10.3390/ijms19124053.
Breast cancer is the most common type of cancer in women. It is a heterogeneous disease that ranges from the less undifferentiated luminal A to the more aggressive basal or triple negative breast cancer molecular subtype. Ca influx from the extracellular medium, but more specifically store-operated Ca entry (SOCE), has been reported to play an important role in tumorigenesis and the maintenance of a variety of cancer hallmarks, including cell migration, proliferation, invasion or epithelial to mesenchymal transition. Breast cancer cells remodel the expression and functional role of the molecular components of SOCE. This review focuses on the functional role and remodeling of SOCE in breast cancer cells. The current studies suggest the need to deepen our understanding of SOCE in the biology of the different breast cancer subtypes in order to develop new and specific therapeutic strategies.
乳腺癌是女性最常见的癌症类型。它是一种异质性疾病，范围从分化程度较低的腔 A 型到侵袭性更强的基底或三阴性乳腺癌分子亚型。细胞外基质中 Ca2+ 的内流，更具体地说是钙库操纵性钙内流（SOCE），已被报道在肿瘤发生和维持多种癌症特征中发挥重要作用，包括细胞迁移、增殖、侵袭或上皮间质转化。乳腺癌细胞重塑 SOCE 的分子组成部分的表达和功能作用。这篇综述重点介绍了 SOCE 在乳腺癌细胞中的功能作用和重塑。目前的研究表明，需要加深对不同乳腺癌亚型中 SOCE 生物学的理解，以便开发新的、更具特异性的治疗策略。
