疫苗接种后的T细胞记忆
T Cell Memory to Vaccination.
作者信息
Todryk Stephen M
机构信息
Department of Applied Sciences, Faculty of Health & Life Sciences, Northumbria University, Newcastle upon Tyne NE1 8ST, UK.
Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
出版信息
Vaccines (Basel). 2018 Dec 14;6(4):84. doi: 10.3390/vaccines6040084.
Abstract
Most immune responses associated with vaccination are controlled by specific T cells of a CD4+ helper phenotype which mediate the generation of effector antibodies, cytotoxic T lymphocytes (CTLs), or the activation of innate immune effector cells. A rapidly growing understanding of the generation, maintenance, activity, and measurement of such T cells is leading to vaccination strategies with greater efficacy and potentially greater microbial coverage.
摘要
大多数与疫苗接种相关的免疫反应由CD4+辅助表型的特定T细胞控制，这些T细胞介导效应抗体、细胞毒性T淋巴细胞（CTL）的产生或先天免疫效应细胞的激活。对这类T细胞的产生、维持、活性及检测的认识迅速增加，正催生出更有效的疫苗接种策略，并有可能扩大微生物覆盖范围。
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