行为变异额颞叶痴呆患者自杀风险高。
High Risk of Suicide in Behavioral Variant Frontotemporal Dementia.
机构信息
1 Department of Neuroscience "Rita Levi Montalcini," Aging Brain and Memory Clinic, University of Torino, Torino, Italy.
2 Department of Neuroscience, Psychology, Drug Research and Child Health (NEUROFARBA), University of Florence, Florence, Italy.
出版信息
Am J Alzheimers Dis Other Demen. 2019 Jun;34(4):265-271. doi: 10.1177/1533317518817609. Epub 2018 Dec 17.
AIM
The purpose of the study was to determine the prevalence of suicidal ideation and attempts in patients with behavioral variant frontotemporal dementia (bvFTD), evaluating possible risk factors for suicidality.
METHODS
Risk of suicide was assessed using the Scale for Suicide Ideation (SSI) in 35 patients with bvFTD and 25 controls.
RESULTS
According to SSI, 40% of patients with bvFTD had suicidal ideation in comparison to 8% of controls ( P = .009). Four patients with bvFTD have attempted suicide versus none control ( P = .006). Patients with bvFTD with suicide risk showed higher levels of anxiety, depression, stress, and hopelessness than patients without suicide risk ( P < .001). Patients who attempted suicide were younger and had a longer disease duration than those with only suicide ideation. Intriguingly, 40% of patients with parkinsonism presented high level of suicide ideation.
CONCLUSIONS
Our findings show that patients with bvFTD have a high risk of suicide. Additional studies in larger populations are needed to confirm our results.
目的
本研究旨在确定行为变异额颞叶痴呆（bvFTD）患者自杀意念和自杀企图的发生率，评估自杀的可能危险因素。
方法
使用自杀意念量表（SSI）评估 35 例 bvFTD 患者和 25 名对照者的自杀风险。
结果
根据 SSI，40%的 bvFTD 患者有自杀意念，而对照组为 8%（P=0.009）。4 例 bvFTD 患者自杀未遂，而对照组无（P=0.006）。有自杀风险的 bvFTD 患者的焦虑、抑郁、压力和绝望水平均高于无自杀风险的患者（P<0.001）。自杀未遂的患者比只有自杀意念的患者更年轻，病程更长。有趣的是，40%的帕金森病患者有高度的自杀意念。
结论
我们的研究结果表明，bvFTD 患者有很高的自杀风险。需要在更大的人群中进行进一步的研究来证实我们的结果。
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