Department of Rheumatology and Immunology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, No. 197 Ruijin Second Road, Shanghai, 200025, China.
State Key Laboratory of Genetic Engineering and Ministry of Education (MOE) Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Fudan University, Shanghai, 200438, China.
BMC Immunol. 2018 Dec 17;19(1):38. doi: 10.1186/s12865-018-0280-x.
Little is known about the presence of specific autoantibodies in ankylosing spondylitis (AS), an immune-mediated inflammatory disease. The object of this study was to explore potential autoantibody profiles in AS patients.
Levels of anti-SIRT1 autoantibodies were significantly higher in AS (P < 0.001) and psoriatic arthritis (PsA) (P < 0.01) patients but not rheumatoid arthritis (RA) patients compared with healthy controls. Additionally, titers of anti-NAD-dependent protein deacetylase sirtuin-1(SIRT1) antibodies were significantly higher in AS patients than in RA (P < 0.05) and PsA (P < 0.05) patients. Moreover, levels of anti-SIRT1 (P < 0.001) antibodies were significantly higher during the first year in patients with hip joint involvement. The anti-SIRT1 antibody positivity rate was 18.9% in AS patients.
Our findings indicate that anti-SIRT1 autoantibodies may serve as a marker for diagnosing AS and predicting hip joint involvement at an early stage.
强直性脊柱炎（AS）是一种免疫介导的炎症性疾病，目前对于其存在特定自身抗体的情况知之甚少。本研究旨在探讨 AS 患者潜在的自身抗体特征。
与健康对照组相比，AS（P<0.001）和银屑病关节炎（PsA）（P<0.01）患者的抗 SIRT1 自身抗体水平显著升高，但类风湿关节炎（RA）患者则不然。此外，AS 患者的抗 NAD 依赖性蛋白去乙酰化酶 SIRT1（SIRT1）抗体滴度也显著高于 RA（P<0.05）和 PsA（P<0.05）患者。此外，髋关节受累患者在第一年中抗 SIRT1 抗体水平显著升高（P<0.001）。AS 患者的抗 SIRT1 抗体阳性率为 18.9%。
我们的研究结果表明，抗 SIRT1 自身抗体可能作为诊断 AS 和预测早期髋关节受累的标志物。
