Sun Haiyang, Li Dong, Wei Chaojie, Liu Liping, Xin Zhuoyuan, Gao Hang, Gao Rong
Department of Immunology, College of Basic Medical Sciences, Jilin University, Changchun, China.
Key Laboratory of Zoonosis Research, Ministry of Education, College of Basic Medical Science, Jilin University, Changchun, China.
Front Immunol. 2024 Nov 29;15:1465849. doi: 10.3389/fimmu.2024.1465849. eCollection 2024.
Recent studies underscore the anti-inflammatory role of SIRT1; however, its levels during inflammatory states remain ambiguous. We synthesized relevant studies up to 20 March 2024 to evaluate the relationship between SIRT1 and inflammation, using data from three major databases. Employing a random-effects model, we analyzed both cross-sectional and longitudinal studies, calculating weighted mean differences (WMDs) for pooled effect sizes. Subgroup and sensitivity analyses, along with a risk of bias assessment, were also conducted. We reviewed 13 publications, encompassing 21 datasets and 2,028 participants. The meta-analysis indicated higher SIRT1 levels in inflammatory groups compared to control groups pre-adjustment (WMD, 3.18 ng/ml; 95% CI 2.30, 4.06 ng/ml; <0.001; = 99.7%) and post-adjustment (WMD, 0.88 ng/ml; 95% CI 0.14, 1.62 ng/ml; <0.001; = 99.5%). Notably, middle-aged patients with inflammation exhibited lower SIRT1 levels (WMD, -0.85 ng/ml; 95% CI -1.47, -0.22 ng/ml; = 0.008; = 95.4%), while groups characterized by East Asian descent, plasma studies, autoimmune conditions, and musculoskeletal disorders showed higher levels. The findings suggest that inflammation generally upregulates SIRT1, potentially elucidating its role in immunobiological processes. However, the significant heterogeneity observed, partly due to the cross-sectional nature of some data, limits insights into the duration of disease progression, which remains highly variable.
近期研究强调了SIRT1的抗炎作用；然而，其在炎症状态下的水平仍不明确。我们综合了截至2024年3月20日的相关研究，利用来自三个主要数据库的数据评估SIRT1与炎症之间的关系。采用随机效应模型，我们分析了横断面研究和纵向研究，计算合并效应量的加权平均差（WMDs）。还进行了亚组分析、敏感性分析以及偏倚风险评估。我们回顾了13篇出版物，涵盖21个数据集和2028名参与者。荟萃分析表明，在调整前，炎症组的SIRT1水平高于对照组（WMD，3.18 ng/ml；95%CI 2.30，4.06 ng/ml；<0.001；I² = 99.7%），调整后也是如此（WMD，0.88 ng/ml；95%CI 0.14，1.62 ng/ml；<0.001；I² = 99.5%）。值得注意的是，患有炎症的中年患者SIRT1水平较低（WMD，-0.85 ng/ml；95%CI -1.47，-0.22 ng/ml；P = 0.008；I² = 95.4%），而以东亚血统、血浆研究、自身免疫性疾病和肌肉骨骼疾病为特征的组显示出较高水平。研究结果表明，炎症通常会上调SIRT1，这可能阐明了其在免疫生物学过程中的作用。然而，观察到的显著异质性，部分归因于一些数据的横断面性质，限制了对疾病进展持续时间的深入了解，疾病进展持续时间仍然高度可变。
