Angle C R
Department of Pediatrics, University of Nebraska Medical Center, Omaha.
Adv Pediatr. 1988;35:239-80.
A major contribution of the pediatrician is to help families rank the multitude of pollutants according to their known risk for child health. Elimination of household smoking and completely effective venting of indoor heating devices are beneficial to all and mandatory in homes of allergic children. Acute releases of NO2 by gas ranges and ovens may be a significant factor in an increased incidence of respiratory infection, especially in children under two years. Despite intensive investigation, immunosuppressive and other health effects have not been defined for indoor levels of PBBs, PCBs, and related halogenated hydrocarbons. The analytic ability to determine nanomolar concentrations of numerous toxic chemicals opens a Pandora's box of inquiry. New methods, particularly immunologic, are urgently needed to quantitate the dose response to multiple combinations of chemicals and determine their significance for the health of the "tight-box" generation of children.
儿科医生的一项主要贡献是帮助家庭根据已知的对儿童健康的风险对众多污染物进行排序。消除家庭吸烟以及使室内取暖设备完全有效通风对所有人都有益，对过敏儿童家庭则是必需的。燃气炉灶和烤箱急性释放二氧化氮可能是呼吸道感染发病率增加的一个重要因素，尤其是对两岁以下的儿童。尽管进行了深入调查，但对于室内多溴联苯、多氯联苯及相关卤代烃的水平，其免疫抑制及其他健康影响尚未明确。测定众多有毒化学物质纳摩尔浓度的分析能力开启了一个探究的潘多拉魔盒。迫切需要新的方法，尤其是免疫学法，来量化对多种化学物质组合的剂量反应，并确定它们对“封闭环境”中成长的这一代儿童健康的意义。
