Mehta N, Boyle G, Bennett D, Gilmour S, Noble M I, Mills C M, Pugh S
Department of Medicine 1, St. George's Hospital Medical School, Midhurst, Sussex, England.
Am Heart J. 1988 Nov;116(5 Pt 1):1298-307. doi: 10.1016/0002-8703(88)90455-3.
Accurate assessment of ascending aortic blood velocity indices and reproducibility of a Doppler ultrasonic system during exercise were determined; the Doppler technique was then used to assess the effects of age, sex, and beta blockade on exercise hemodynamics. Doppler-determined velocity correlated well with an invasive electromagnetic system. Reproducibility of Doppler variables during three exercise tests was high (coefficient of variation less than 10%) and did not deteriorate appreciably with exercise. Peak velocity (PV) and maximum acceleration (MA) were inversely related to age, the relationship being more significant during exercise, whereas the systolic velocity integral showed no such relationship either at rest or during exercise. Doppler variables showed no difference between sexes, except at high levels of exercise. Beta blockade markedly attenuated the exercise response as shown by significant decreases in both MA and PV during exercise. The Doppler velocity data presented in this study provide a reference against which previously documented changes in exercising ischemic patients can be better related.
确定了运动期间多普勒超声系统对升主动脉血流速度指数的准确评估及其可重复性；然后使用多普勒技术评估年龄、性别和β受体阻滞剂对运动血流动力学的影响。多普勒测定的速度与侵入性电磁系统相关性良好。三次运动测试期间多普勒变量的可重复性很高（变异系数小于10%），并且不会因运动而明显恶化。峰值速度（PV）和最大加速度（MA）与年龄呈负相关，这种关系在运动期间更为显著，而收缩期速度积分在静息或运动期间均未显示出这种关系。除了在高强度运动时，多普勒变量在性别之间没有差异。β受体阻滞剂显著减弱了运动反应，运动期间MA和PV均显著降低。本研究中呈现的多普勒速度数据提供了一个参考，据此可以更好地关联先前记录的运动性缺血患者的变化。
