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对传统治疗有抵抗性的严重水杨酸盐中毒

Severe salicylate poisoning resistant to conventional management.

作者信息

Akshintala Divya, Mendez Anjeanette, Ikladios Ossama I, Emani Vamsi Krishna

机构信息

Division of Endocrinology, University of Florida, Gainesville, FL, USA.

Division of General Internal Medicine, University of Illinois College of Medicine at Peoria, Peoria, IL, USA.

出版信息

J Community Hosp Intern Med Perspect. 2018 Dec 11;8(6):373-375. doi: 10.1080/20009666.2018.1551027. eCollection 2018.

DOI:10.1080/20009666.2018.1551027
PMID:30559949
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6292349/
Abstract

Aspirin remains one of the most common agents involved in both accidental and intentional overdose. The availability of enhanced elimination and early hemodialysis has been known to reduce the number of deaths from salicylate poisoning. We present the case of an intentional aspirin overdose with enteric-coated preparation that had continuously rising salicylate levels despite treatment with bicarbonate drip, continuous dialysis and activated charcoal.

摘要

阿司匹林仍然是意外和故意过量服用中最常见的药物之一。已知强化清除和早期血液透析的可用性可减少水杨酸盐中毒导致的死亡人数。我们报告一例故意过量服用肠溶制剂阿司匹林的病例，尽管进行了碳酸氢盐滴注、持续透析和活性炭治疗，但水杨酸盐水平仍持续上升。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a7dd/6292349/6065c95be024/ZJCH_A_1551027_UF0001_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a7dd/6292349/cbec018e9993/ZJCH_A_1551027_F0001_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a7dd/6292349/6065c95be024/ZJCH_A_1551027_UF0001_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a7dd/6292349/cbec018e9993/ZJCH_A_1551027_F0001_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a7dd/6292349/6065c95be024/ZJCH_A_1551027_UF0001_OC.jpg

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引用本文的文献

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Failure of Computed Tomography (CT) in Detecting an Aspirin Pharmacobezoar: A Case Report.CT 检测阿司匹林药源性胃石失败 1 例报告
Am J Case Rep. 2022 Dec 20;23:e936752. doi: 10.12659/AJCR.936752.

本文引用的文献

1
Death due to acute salicylate intoxication despite dialysis.尽管进行了透析，但仍死于急性水杨酸盐中毒。
J Emerg Med. 2011 May;40(5):515-7. doi: 10.1016/j.jemermed.2010.02.015. Epub 2010 Mar 29.
2
The underutilization of hemodialysis in patients with salicylate poisoning.
Kidney Int. 2009 Jun;75(12):1349-1353. doi: 10.1038/ki.2008.443. Epub 2008 Aug 20.
3
Emergency department management of the salicylate-poisoned patient.急诊科对水杨酸盐中毒患者的管理。
Emerg Med Clin North Am. 2007 May;25(2):333-46; abstract viii. doi: 10.1016/j.emc.2007.02.012.
4
Pharmacobezoar: an evolving new entity.药物性胃石：一个不断演变的新实体。
Dig Dis. 1995 Nov-Dec;13(6):356-64. doi: 10.1159/000171515.
5
Enteric-coated aspirin bezoar: elevation of serum salicylate level by barium study. Case report and review of medical management.肠溶阿司匹林胃石症：钡剂造影检查发现血清水杨酸水平升高。病例报告及内科治疗综述
Am J Med. 1987 Oct;83(4):783-6. doi: 10.1016/0002-9343(87)90915-6.