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本文引用的文献

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[Multiple chemical sensitivity].[多重化学敏感性]
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2
The idiopathic environmental intolerance symptom inventory: development, evaluation, and application.特发性环境不耐受症状量表:编制、评估与应用
J Occup Environ Med. 2009 Jul;51(7):838-47. doi: 10.1097/JOM.0b013e3181a7f021.
3
The German Multicentre Study on Multiple Chemical Sensitivity (MCS).德国多化学物质敏感症多中心研究(MCS)。
Int J Hyg Environ Health. 2008 Oct;211(5-6):658-81. doi: 10.1016/j.ijheh.2008.03.002. Epub 2008 May 27.
4
[Multiple chemical sensitivity: study of 52 cases].[多重化学物质敏感症:52例病例研究]
Med Clin (Barc). 2007 Jun 16;129(3):96-8; quiz 99. doi: 10.1157/13107370.
5
[Multiple chemical sensitivity, a disease commonly missed].[多重化学物质敏感症,一种常被漏诊的疾病]
Med Clin (Barc). 2005 Sep 3;125(7):257-62. doi: 10.1157/13078105.
6
Multiple chemical sensitivity syndrome (MCS)--suggestions for an extension of the U.S. MCS-case definition.多重化学敏感性综合征(MCS)——关于扩展美国MCS病例定义的建议
Int J Hyg Environ Health. 2005;208(3):141-51. doi: 10.1016/j.ijheh.2005.01.017.
7
National prevalence of asthma and chemical hypersensitivity: an examination of potential overlap.全国哮喘和化学物质超敏反应的患病率:对潜在重叠情况的调查。
J Occup Environ Med. 2005 May;47(5):518-22. doi: 10.1097/01.jom.0000161736.54099.44.
8
Chromosomal aberration analysis in workers exposed to chemical and biological hazards in research laboratories.研究实验室中接触化学和生物危害的工作人员的染色体畸变分析。
Environ Res. 2005 Mar;97(3):330-4. doi: 10.1016/j.envres.2004.09.013.
9
Exposure to chemical carcinogens and risk of cancer among Finnish laboratory workers.芬兰实验室工作人员接触化学致癌物与癌症风险
Am J Ind Med. 2003 Oct;44(4):343-50. doi: 10.1002/ajim.10278.
10
Mechanisms of multiple chemical sensitivity.多重化学物质敏感症的机制。
Toxicol Lett. 2002 Mar 10;128(1-3):85-97. doi: 10.1016/s0378-4274(01)00536-7.

化学实验室工作人员的多重化学物质敏感症

Multiple Chemical Sensitivity in Chemical Laboratory Workers.

作者信息

Pérez-Crespo Juan, Lobato-Cañón Rafael, Solanes-Puchol Ángel

机构信息

Health & Safety Office, Miguel Hernández University, Elche, Spain.

Department of Pathology and Surgery, Miguel Hernández University, Elche, Spain.

出版信息

Saf Health Work. 2018 Dec;9(4):473-478. doi: 10.1016/j.shaw.2018.03.001. Epub 2018 Mar 9.

DOI:10.1016/j.shaw.2018.03.001
PMID:30559998
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6284157/
Abstract

BACKGROUND

Multiple Chemical Sensitivity (MCS) is an acquired disease which etiology remains unknown. It is characterized by the development of sensitivity to certain chemical products.Most of the hypotheses formulated to explain the syndrome associate it to a previous exposition to some kind of volatile chemical. University researchers in chemical laboratories suffer a phenomenon of multi-exposition to chemical agents at low concentration during long periods of time although in an irregular form. Many of these chemical agents have similar properties to those suspicious of causing MCS. This article studies the prevalence of MCS in laboratory researchers.

METHODS

The study group is university researchers in chemical laboratories. The control group was obtained from administrative personnel who work in the same universities and therefore, are not exposed to chemical products from the laboratories, but have the same exposition to the rest of environmental polluting agents from the area and from the buildings of the university. In this study, it is used the Quick Environmental Exposure and Sensitivity Inventory (QEESI) (sensitivity of 92%/specificity of 95%).

RESULTS

The results showed that the prevalence of MCS for the university researchers is not related to exposition by inhalation to multiple chemical agents, at low concentration.

CONCLUSIONS

The results disagree with one of the main etiological hypotheses of MCS, which is based on the existence of hypersensitive people, who presents a response after prolonged expositions to very low concentrations during a long period of time.

摘要

背景

多重化学敏感性(MCS)是一种病因不明的后天性疾病。其特征是对某些化学产品产生敏感性。为解释该综合征而提出的大多数假说都将其与先前接触某种挥发性化学物质联系起来。化学实验室的大学研究人员在长时间内会不定期地遭受低浓度化学试剂的多重接触。其中许多化学试剂的性质与那些疑似导致MCS的化学物质相似。本文研究了实验室研究人员中MCS的患病率。

方法

研究组为化学实验室的大学研究人员。对照组来自同一所大学的行政人员,因此他们不接触实验室的化学产品,但对该地区和大学校园内的其他环境污染物接触情况相同。在本研究中,使用了快速环境暴露与敏感性量表(QEESI)(敏感性为92%/特异性为95%)。

结果

结果表明,大学研究人员中MCS的患病率与低浓度吸入多种化学试剂无关。

结论

该结果与MCS的主要病因假说之一不一致,该假说基于存在过敏人群,他们在长时间接触极低浓度物质后会出现反应。