硒醇类：一类新型碳酸酐酶抑制剂。
Selenols: a new class of carbonic anhydrase inhibitors.
机构信息
University of Florence, NEUROFARBA Department, Sezione di Scienze Farmaceutiche, Via Ugo Schiff 6, 50019 Sesto Fiorentino, Florence, Italy.
出版信息
Chem Commun (Camb). 2019 Jan 10;55(5):648-651. doi: 10.1039/c8cc08562e.
PMID:30560259
Abstract
Stable aryl selenols were obtained through a convenient procedure. Selenols represent a new chemotype acting as carbonic anhydrase inhibitors (CAIs), inhibiting four human isoforms, CAs I, II, VII and the tumor-associated CA IX. X-ray crystallographic, physical and computational studies provided insights into the binding mode of this conceptually new class of CAIs.
摘要
稳定的芳基硒醇是通过一种简便的方法得到的。硒醇代表了一种新的化学型，作为碳酸酐酶抑制剂（CAIs），抑制四种人同工酶，即 CA I、CA II、CA VII 和与肿瘤相关的 CA IX。X 射线晶体学、物理和计算研究提供了对这种新概念 CAIs 结合模式的深入了解。
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