[高同型半胱氨酸血症与肾脏疾病]

[Hyperhomocysteinemia and kidney diseases].

作者信息

Zhou Yun-Feng, Guan You-Fei

机构信息

Medical Research Center, Physiology Department of Basic Medical College, Shenzhen University Health Science Center, Shenzhen 518060, China.

Advanced Institute of Medical Sciences, Dalian Medical University, Dalian 116044, China.

出版信息

Sheng Li Xue Bao. 2018 Dec 25;70(6):607-611.

PMID:30560269

Abstract

Homocysteine (Hcy) is an intermediate metabolite of methionine metabolism. Hyperhomocysteinemia (HHcy) is defined as a condition characterized by plasma Hcy level above 16 μmol/L which can result from abnormal Hcy metabolism. HHcy has been confirmed to be related to cardio-cerebrovascular disease, peripheral vascular disorders, neurodegenerative diseases, diabetes, pregnancy-induced hypertension syndrome, liver cirrhosis and kidney diseases. In this review, we summarize the correlation between HHcy and kidney diseases. Elucidating the role of HHcy in kidney diseases may provide a new strategy to prevent and treat kidney diseases.

摘要

同型半胱氨酸（Hcy）是蛋氨酸代谢的中间产物。高同型半胱氨酸血症（HHcy）被定义为一种以血浆Hcy水平高于16μmol/L为特征的病症，其可由Hcy代谢异常引起。HHcy已被证实与心脑血管疾病、外周血管疾病、神经退行性疾病、糖尿病、妊娠高血压综合征、肝硬化和肾脏疾病有关。在本综述中，我们总结了HHcy与肾脏疾病之间的相关性。阐明HHcy在肾脏疾病中的作用可能为预防和治疗肾脏疾病提供新策略。