C2VN (AMU - Inserm1263 - Inrae 1260), Aix-Marseille Université - Campus Santé Timone - Faculté de Pharmacie, Marseille, France, Laboratory of Biochemistry, Hôpital de La Timone, Marseille, France.
C2VN (AMU - Inserm1263 - Inrae 1260), Aix-Marseille Université - Campus Santé Timone - Faculté de Pharmacie, Marseille, France.
Ann Biol Clin (Paris). 2022 Feb 1;80(1):7-14. doi: 10.1684/abc.2021.1694.
Homocysteine (Hcy) is a sulfhydryl-containing amino acid, which is not acquired through the diet, but rather synthesized as an intermediate metabolite in the methionine cycle. Hcy is present in plasma, with normal levels between 5 and 15 μmol/L, a slightly elevated level between 15 to 30 μmol/L, moderate from 30 to 100 μmol/L and a value > 100 μmol/L classified as severe hyperhomocysteinemia (HHcy). HHcy has been associated with inflammation and atherosclerosis and is considered an independent risk factor for cardiovascular diseases (CVD). Here, we review the main evidence showing the association and the possible involvement of HHcy in the most common CVD.
同型半胱氨酸（Hcy）是一种含巯基的氨基酸，不能通过饮食获得，而是作为蛋氨酸循环中的中间代谢产物合成。Hcy 存在于血浆中，正常水平在 5 到 15μmol/L 之间，15 到 30μmol/L 之间略有升高，30 到 100μmol/L 之间为中度升高，>100μmol/L 则被归类为严重高同型半胱氨酸血症（HHcy）。HHcy 与炎症和动脉粥样硬化有关，被认为是心血管疾病（CVD）的独立危险因素。在这里，我们回顾了主要的证据，表明 HHcy 与最常见的 CVD 之间存在关联，并可能涉及其中。
