Division of Gastroenterology and Hepatology, Department of Medicine, The Pennsylvania State University Milton S. Hershey Medical Center, 500 University Drive, Hershey, PA, 17033, USA.
Department of Public Health Sciences, The Pennsylvania State University Milton S. Hershey Medical Center, Hershey, PA, USA.
Dig Dis Sci. 2019 Mar;64(3):619-626. doi: 10.1007/s10620-018-5427-3.
Non-tumoral portal vein thrombosis (PVT) remains a highly relevant topic in the field of hepatology and liver transplantation with much surrounding controversy. Although multiple studies have shown that PVT is associated with adverse outcomes with increased morbidity and mortality rates, others have not reported the same clinical impact of PVT, arguing rather that incident PVT reflects worsening portal hypertension and the natural history of the disease. Despite this uncertainly, PVT is a dilemma facing the clinician on a daily basis often requiring a multidisciplinary team-based approach between hepatologists, transplant surgeons, interventional radiologists and hematologists. In this review, the authors provide a summary of the evidence supporting best clinical practices in the management of non-tumoral PVT in patients with cirrhosis.
非肿瘤性门静脉血栓形成（PVT）仍然是肝病学和肝移植领域的一个重要话题，存在许多争议。尽管多项研究表明 PVT 与不良预后相关，发病率和死亡率增加，但其他研究并未报告 PVT 具有相同的临床影响，而是认为偶发性 PVT 反映了门静脉高压的恶化和疾病的自然病程。尽管存在这种不确定性，但 PVT 是临床医生每天都会面临的困境，通常需要肝科医生、移植外科医生、介入放射科医生和血液科医生之间的多学科团队方法。在这篇综述中，作者总结了支持肝硬化患者非肿瘤性 PVT 管理最佳临床实践的证据。
