Department of Biochemistry and Molecular Genetics, College of Medicine, University of Illinois at Chicago, Chicago, IL, USA.
Research & Development Section, Jesse Brown VA Medical Center, Chicago, IL, USA.
Nat Rev Endocrinol. 2019 Feb;15(2):71-72. doi: 10.1038/s41574-018-0146-6.
Cancer cells consume and utilize glucose at a higher rate than normal cells. However, some microenvironments limit the availability of nutrients and glucose. In 2018, researchers found that tumours depend on a variety of different nutrient sources, both locally and systemically, to overcome metabolic limitations and promote tumour progression and metastasis.
癌细胞比正常细胞消耗和利用葡萄糖的速度更快。然而,一些微环境限制了营养物质和葡萄糖的可利用性。2018 年,研究人员发现,肿瘤依赖于各种不同的营养来源,包括局部和全身的来源,以克服代谢限制,促进肿瘤的进展和转移。