Institute of Reproductive Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
C.S. Mott Center for Human Growth and Development, Wayne State University School of Medicine, Detroit, MI, United States.
Front Immunol. 2020 Feb 27;11:279. doi: 10.3389/fimmu.2020.00279. eCollection 2020.
Aerobic glycolysis is a recognized feature shared by tumors, leading to the accumulation of lactic acid in their local microenvironments. Like the tumors, the blastocysts, placenta, trophoblasts and decidual immune cells can also produce a large amount of lactic acid through aerobic glycolysis during the early pregnancy. Moreover, the placenta expresses the transporters of the lactic acid. While several studies have described the role of lactic acid in the tumor microenvironment, especially lactic acid's modulation of immune cells, the role of lactic acid produced during pregnancy is still unclear. In this paper, we reviewed the scientific evidence detailing the effects of lactic acid in the tumor microenvironment. Based on the influence of the lactic acid on immune cells and tumors, we proposed that lactic acid released in the unique uterine environment could have similar effects on the trophoblast cells and immune cells during the early pregnancy.
有氧糖酵解是肿瘤的一个公认特征，导致乳酸在其局部微环境中积累。与肿瘤类似，囊胚、胎盘、滋养层细胞和蜕膜免疫细胞在早孕期间也可以通过有氧糖酵解产生大量乳酸。此外，胎盘表达乳酸的转运体。虽然有几项研究描述了乳酸在肿瘤微环境中的作用，特别是乳酸对免疫细胞的调节作用，但妊娠期间产生的乳酸的作用尚不清楚。在本文中，我们综述了详细描述乳酸在肿瘤微环境中作用的科学证据。基于乳酸对免疫细胞和肿瘤的影响，我们提出在独特的子宫环境中释放的乳酸可能对早孕期间的滋养层细胞和免疫细胞产生类似的作用。
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