Department of General Thoracic Surgery, Dokkyo Medical University School of Medicine, Tochigi, Japan.
Department of Diagnostic Pathology, Dokkyo Medical University School of Medicine, Tochigi, Japan.
Thorac Cancer. 2019 Feb;10(2):219-225. doi: 10.1111/1759-7714.12935. Epub 2018 Dec 18.
Tumor infiltrating lymphocytes (TILs) are known to correlate with the prognosis of patients affected by a variety of cancer types. We evaluated TILs in patients who underwent surgery for lung squamous cell carcinoma (SCC).
Specimens obtained from patients during resection of lung SCC were examined for TIL density, lymphoid follicle formation, PD-L1 expression, and the appearance of regulatory T cells (Tregs).
We enrolled 72 patients who underwent surgery for SCC (TIL grades 0, 1, and 2: 29, 18, and 25, respectively). Lymphoid follicles were observed in 13 (18.1%) patients and 8 were positive for Tregs, which were always observed in association with lymphoid follicles (P < 0.001). Multivariate analysis revealed that lymphoid follicle formation, the appearance of Tregs, pathological stage, and pleural invasion were independent prognostic factors related to overall survival, whereas TIL density and PD-L1 expression were not.
SCC patients with lymphoid follicle formation accompanied by Tregs show poor survival following lung resection surgery.
肿瘤浸润淋巴细胞（TILs）与多种癌症类型患者的预后相关。我们评估了接受肺鳞癌（SCC）手术治疗的患者的 TILs。
对接受 SCC 切除术的患者标本进行 TIL 密度、淋巴滤泡形成、PD-L1 表达和调节性 T 细胞（Tregs）外观的检查。
我们纳入了 72 名接受 SCC 手术治疗的患者（TIL 分级 0、1 和 2 分别为 29、18 和 25）。13 名（18.1%）患者观察到淋巴滤泡，8 名患者 Tregs 阳性，Tregs 总是与淋巴滤泡同时存在（P < 0.001）。多因素分析显示，淋巴滤泡形成、Tregs 出现、病理分期和胸膜侵犯是与总生存相关的独立预后因素，而 TIL 密度和 PD-L1 表达则不是。
伴有 Tregs 的淋巴滤泡形成的 SCC 患者在接受肺切除手术后生存较差。
