Bento Diana Costa, Jones Emma, Junaid Syed, Tull Justyna, Williams Geraint T, Godkin Andrew, Ager Ann, Gallimore Awen
Infection and Immunity; School of Medicine; Henry Wellcome Building; Cardiff University ; Cardiff, UK.
Institute of Medical Genetics; University Hospital of Wales ; Cardiff, UK.
Oncoimmunology. 2015 Apr 2;4(3):e974374. doi: 10.4161/2162402X.2014.974374. eCollection 2015 Mar.
Prolonged patient survival after surgical resection, is associated with a higher cytotoxic and memory T cell density within colorectal cancers (CRC). High endothelial venules (HEVs) are specialized blood vessels present in secondary lymphoid organs (SLO) that allow ingress of naïve and central memory T cells from the blood. It has been proposed that HEVs in tumors might serve as a similar route of entry for lymphocytes into the tumor and result in an improved prognosis. The present study aimed to characterize HEVs and their microenvironment in resected tumors from colorectal cancer patients ( = 62). We observed HEVs in association with lymphoid aggregates in 49 out of 62 patients. However, these HEV lymphoid aggregates were largely at the invasive margin of the tumor and although there was an association with lymphocytes and HEVs at the invasive margin ( = 0.002) there was only a very weak association with tumor infiltrating lymphocytes. Indeed, lymphoid aggregates were associated with more advanced disease (Dukes' stage C) and did not indicate a favorable prognosis.
手术切除后患者长期存活与结直肠癌（CRC）中较高的细胞毒性和记忆T细胞密度相关。高内皮微静脉（HEV）是存在于二级淋巴器官（SLO）中的特殊血管，可使幼稚和中枢记忆T细胞从血液进入。有人提出肿瘤中的HEV可能作为淋巴细胞进入肿瘤的类似途径，并导致预后改善。本研究旨在表征结直肠癌患者切除肿瘤（n = 62）中的HEV及其微环境。我们在62例患者中的49例中观察到与淋巴样聚集相关的HEV。然而，这些HEV淋巴样聚集主要位于肿瘤的浸润边缘，尽管在浸润边缘淋巴细胞与HEV有关联（P = 0.002），但与肿瘤浸润淋巴细胞的关联非常弱。事实上，淋巴样聚集与更晚期疾病（Dukes分期C期）相关，并不预示良好预后。
