温和、直接的芳杂环 sp³ C-H 硅醚化反应。
A Mild and Direct Site-Selective sp C-H Silylation of (Poly)Azines.
机构信息
Institute of Chemical Research of Catalonia (ICIQ), The Barcelona Institute of Science and Technology , Av. Països Catalans 16 , 43007 Tarragona , Spain.
Departament de Química Analítica i Química Orgànica , Universitat Rovira i Virgili , c/Marcel·lí Domingo, 1 , 43007 Tarragona , Spain.
出版信息
J Am Chem Soc. 2019 Jan 9;141(1):127-132. doi: 10.1021/jacs.8b12063. Epub 2018 Dec 21.
A base-mediated protocol that allows for the site-selective sp C-H silylation of azines is described. This method is distinguished by its mild conditions, simplicity and excellent site-selective modulation for a diverse set of azines, even in the context of late-stage functionalization, while exhibiting orthogonal reactivity with classical silylation reactions.
描述了一种基于碱的协议，该协议允许嗪的位置选择性 sp C-H 硅烷化。该方法的特点是条件温和、简单，对各种嗪具有优异的位置选择性调节能力，即使在晚期功能化的情况下也是如此，同时与经典的硅烷化反应表现出正交反应性。
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