宋内志贺菌中与质粒编码的 I 型二氢叶酸还原酶相关的对甲氧苄啶的高水平耐药性。
High-level resistance to trimethoprim in Shigella sonnei associated with plasmid-encoded dihydrofolate reductase type I.
作者信息
Delgado R, Otero J R
机构信息
Servicio de Microbiología, Hospital Primero de Octubre, Madrid, Spain.
出版信息
Antimicrob Agents Chemother. 1988 Oct;32(10):1598-9. doi: 10.1128/AAC.32.10.1598.
Abstract
By DNA hybridization, the gene encoding dihydrofolate reductase type I was found in 58 of 59 highly trimethoprim-resistant clinical isolates of Shigella sonnei obtained from 1981 through 1987 in Madrid, Spain. No strain harbored the type II gene. In selected strains, the type I gene was demonstrated to be in a plasmid.
摘要
通过DNA杂交技术，在1981年至1987年从西班牙马德里获得的59株高度耐甲氧苄啶的宋内志贺氏菌临床分离株中，有58株发现了编码I型二氢叶酸还原酶的基因。没有菌株携带II型基因。在选定的菌株中，I型基因被证明存在于质粒中。
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