Heikkilä E, Sundström L, Huovinen P
Department of Medical Microbiology, Turku University, Finland.
Antimicrob Agents Chemother. 1990 Oct;34(10):2013-5. doi: 10.1128/AAC.34.10.2013.
The frequency of trimethoprim resistance among Escherichia coli isolates from urine samples collected at Turku City Hospital, Turku, Finland, remained at 40% during 1984 to 1988. The proportion of highly resistant (MIC, greater than or equal to 1,024 micrograms/ml) isolates increased, however, and most of these harbored the type I dihydrofolate reductase gene. Only a few isolates possessed type II or VII genes.
1984年至1988年期间，从芬兰图尔库市立医院采集的尿液样本中分离出的大肠杆菌对甲氧苄啶耐药的频率维持在40%。然而，高耐药性（最低抑菌浓度大于或等于1024微克/毫升）菌株的比例有所增加，其中大多数携带I型二氢叶酸还原酶基因。只有少数菌株拥有II型或VII型基因。
