Section of Digestive Diseases, Department of Internal Medicine, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520-8019, USA.
Department of Biochemistry and Immunology, Federal University of Minas Gerais. Av. Antônio Carlos, 6627, Belo Horizonte-MG 31270-901, Brazil.
Int J Mol Sci. 2018 Dec 6;19(12):3913. doi: 10.3390/ijms19123913.
Calcium (Ca) is a versatile second messenger that regulates a number of cellular processes in virtually every type of cell. The inositol 1,4,5-trisphosphate receptor (ITPR) is the only intracellular Ca release channel in cholangiocytes, and is therefore responsible for Ca-mediated processes in these cells. This review will discuss the machinery responsible for Ca signals in these cells, as well as experimental models used to investigate cholangiocyte Ca signaling. We will also discuss the role of Ca in the normal and abnormal regulation of secretion and apoptosis in cholangiocytes, two of the best characterized processes mediated by Ca in this cell type.
钙（Ca）是一种多功能的第二信使，几乎可以调节所有类型细胞中的多种细胞过程。肌醇 1,4,5-三磷酸受体（ITPR）是胆管细胞中唯一的细胞内 Ca 释放通道，因此负责这些细胞中的 Ca 介导过程。本综述将讨论这些细胞中 Ca 信号的机制，以及用于研究胆管细胞 Ca 信号的实验模型。我们还将讨论 Ca 在胆管细胞的正常和异常分泌以及凋亡调节中的作用，这是该细胞类型中 Ca 介导的两个最佳特征过程。
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