钙信号传导与胆管上皮细胞的分泌活性
Calcium signaling and the secretory activity of bile duct epithelia.
作者信息
Amaya Maria Jimena, Nathanson Michael H
机构信息
Section of Digestive Diseases, Department of Internal Medicine, Yale University, 333 Cedar Street, PO Box 208019, New Haven, CT 06520-8019, USA.
Section of Digestive Diseases, Department of Internal Medicine, Yale University, 333 Cedar Street, PO Box 208019, New Haven, CT 06520-8019, USA.
出版信息
Cell Calcium. 2014 Jun;55(6):317-24. doi: 10.1016/j.ceca.2014.02.003. Epub 2014 Feb 12.
Cytosolic calcium (Cai(2+)) is a second messenger that is important for the regulation of secretion in many types of tissues. Bile duct epithelial cells, or cholangiocytes, are polarized epithelia that line the biliary tree in liver and are responsible for secretion of bicarbonate and other solutes into bile. Cai(2+) signaling plays an important role in the regulation of secretion by cholangiocytes, and this review discusses the machinery involved in the formation of Ca(2+) signals in cholangiocytes, along with the evidence that these signals regulate ductular secretion. Finally, this review discusses the evidence that impairments in cholangiocyte Ca(2+) signaling play a primary role in the pathogenesis of cholestatic disorders, in which hepatic bile secretion is impaired.
胞质钙（Ca i(2+)）是一种第二信使，对多种组织中的分泌调节至关重要。胆管上皮细胞，即胆管细胞，是排列在肝脏胆管树内的极化上皮细胞，负责将碳酸氢盐和其他溶质分泌到胆汁中。Ca i(2+)信号在胆管细胞分泌调节中起重要作用，本综述讨论了胆管细胞中Ca(2+)信号形成所涉及的机制，以及这些信号调节胆小管分泌的证据。最后，本综述讨论了胆管细胞Ca(2+)信号受损在胆汁淤积性疾病发病机制中起主要作用的证据，胆汁淤积性疾病中肝胆汁分泌受损。
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