Mikić Mišel, Šestak Anamarija, Volarić Mile, Rudan Stjepan, Trtica Majnarić Ljiljana
General Hospital Vinkovci, Emergency Admission Unit Laboratory, Vladimira Gortana 25, 32100 Vinkovci, Croatia.
Faculty of Medicine, Josip Juraj Strossmayer University of Osijek, Josipa Huttlera 4, 31000 Osijek, Croatia.
J Clin Med. 2018 Dec 6;7(12):520. doi: 10.3390/jcm7120520.
The seasonality of acute myocardial infarction and progressive heart failure has been well established so far. Cardiac troponins (cTns) are organ-specific, not disease-specific, biomarkers. The seasonality of cTns has not been reported before.
Data were collected from the emergency admission unit of a community hospital in eastern Croatia for each month of the year 2014 covering the number of patients whose doctors requested high-sensitivity cTn I (hs-cTn I) testing, the number of positive test results and hospital admissions.
The proportion of patients with positive test results was 15.75% (350 patients out of 2221 patients referred to testing), with the males being outnumbered by the females (F: 57.15%, M: 42.85%) ( = 0.069). The month with the highest number of patients with positive test results was December, whereas the month with the lowest number of those patients was January ( < 0.001). The highest numbers of patients referred to testing (30.9%) and of those with positive test results (50.8%) were found in the oldest age group (76+).
Tracking the results of cTns testing during patient admissions to emergency departments would be a more effective approach from a public health perspective than tracking the number of patients diagnosed with a particular cardiovascular (CV) disease and could be used as a research approach to guide a search for precipitating factors for CV disease specific to a local community.
急性心肌梗死和进行性心力衰竭的季节性迄今已得到充分证实。心肌肌钙蛋白（cTn）是器官特异性而非疾病特异性生物标志物。此前尚未报道过cTn的季节性。
收集了克罗地亚东部一家社区医院急诊科2014年每个月的数据，内容包括医生要求进行高敏肌钙蛋白I（hs-cTn I）检测的患者数量、检测阳性结果数量及住院人数。
检测阳性结果患者的比例为15.75%（2221例接受检测的患者中有350例），女性患者多于男性患者（女性：57.15%，男性：42.85%）（P = 0.069）。检测阳性结果患者数量最多的月份是12月，而该类患者数量最少的月份是1月（P < 0.001）。在年龄最大的年龄组（76岁及以上）中，接受检测的患者数量最多（30.9%），检测阳性结果的患者数量也最多（50.8%）。
从公共卫生角度来看，在患者急诊入院期间追踪cTn检测结果比追踪诊断为特定心血管（CV）疾病的患者数量更有效，并且可以作为一种研究方法来指导寻找当地社区特有的CV疾病诱发因素。
