Li Zhen, Zhang Li, Wei Xilian, Liu Jie, Wang Zhongni
College of Chemistry, Chemical Engineering and Materials Science , Shandong Normal University , Jinan 250014 , China.
College of Chemistry and Chemical Engineering , Liaocheng University , Liaocheng 252000 , China.
Langmuir. 2019 Jan 15;35(2):453-460. doi: 10.1021/acs.langmuir.8b03559. Epub 2018 Dec 31.
The temperature/pH-responsive hexagonal liquid crystal constructed in a polyoxyethylene (20) sorbitan monooleate (Tween 80)/water-soluble chitosan (WCS)/ethyl oleate (EtOL)/HO system was used to encapsulate curcumin. We discuss the effect of temperature and pH on the in vitro release of curcumin and the rheological properties of a curcumin-encapsulated liquid crystal. The drug-encapsulated hexagonal phase containing relatively high WCS content (9.9 wt %) exhibited good temperature response, as indicated by three phase transformation temperature obtained by temperature scanning. The viscosity of the drug-encapsulated hexagonal phase decreased as the temperature rose, which exhibited diverse constancy and temperature sensitivity. Also, the in vitro release rate of curcumin increased as the temperature increased. After introducing WCS, the release rate of curcumin decreased obviously the pH dependence, where the release of curcumin was slower as the pH was higher. All of the results indicated that the temperature/pH-responsive hexagonal liquid crystals were proposed to be potential slow release carriers to deliver curcumin.
在聚氧乙烯（20）山梨醇酐单油酸酯（吐温80）/水溶性壳聚糖（WCS）/油酸乙酯（EtOL）/水体系中构建的温度/pH响应型六方液晶用于包封姜黄素。我们讨论了温度和pH对姜黄素体外释放以及包封姜黄素的液晶流变学性质的影响。通过温度扫描获得的三个相变温度表明，含有相对较高WCS含量（9.9 wt%）的药物包封六方相表现出良好的温度响应。包封药物的六方相的粘度随着温度升高而降低，表现出不同的恒定性和温度敏感性。此外，姜黄素的体外释放速率随着温度升高而增加。引入WCS后，姜黄素的释放速率明显降低了对pH的依赖性，其中pH越高，姜黄素的释放越慢。所有结果表明，温度/pH响应型六方液晶有望成为递送姜黄素的潜在缓释载体。
