School of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou 225002, P. R. China.
Langmuir. 2021 Jun 15;37(23):7067-7077. doi: 10.1021/acs.langmuir.1c00659. Epub 2021 Jun 3.
Lamellar liquid crystals have amazing lubricating and drug-solubilizing properties. Hence, the combination of drug molecules with lamellar liquid crystals is expected to be used in joint lubrication and treatment. In this study, the partial phase diagram of the Tween 85/Tween 80/HO three-component system was determined. The phase structure of the system changed from a hexagonal liquid crystal to a lamellar liquid crystal with the increase of Tween 85 content. The lamellar liquid crystals showed superior lubricating properties due to their unique lamellar structure. Furthermore, the model of drug release during friction was established for the first time. It was found that the order of the lamellar liquid crystals increased with the increase of the mass ratio of Tween 85/Tween 80, leading to the decrease of the ibuprofen release rate. In addition, the release rate of ibuprofen increased progressively with the increase of the friction frequency, but the load had little effect on it. Therefore, the lamellar liquid crystals consisting of nonionic surfactants with good biocompatibility have potential application prospects for joint lubrication and treatment of arthritis.
层状液晶具有优异的润滑和药物增溶性能。因此，将药物分子与层状液晶结合有望用于关节润滑和治疗。本研究确定了 Tween 85/Tween 80/HO 三组分体系的部分相图。随着 Tween 85 含量的增加，体系的相结构从六方液晶转变为层状液晶。层状液晶由于其独特的层状结构表现出优异的润滑性能。此外，首次建立了摩擦过程中药物释放的模型。结果发现，随着 Tween 85/Tween 80 质量比的增加，层状液晶的有序度增加，导致布洛芬的释放速率降低。此外，布洛芬的释放速率随着摩擦频率的增加而逐渐增加，但负载对其影响很小。因此，由具有良好生物相容性的非离子表面活性剂组成的层状液晶在关节润滑和关节炎治疗方面具有潜在的应用前景。
