Owen I L
National Veterinary Laboratory, Department of Agriculture & Livestock, Boroko, Papua New Guinea.
Aust Vet J. 1988 Sep;65(9):267-70. doi: 10.1111/j.1751-0813.1988.tb16140.x.
Sheep treated once with closantel at 7.5 or 15.0 mg/kg and grazing with untreated sheep remained free of Haemonchus contortus for at least 4 to 5 weeks and 6 to 7 weeks respectively after treatment. When the whole flock was treated with 15.0 mg/kg, H. contortus began to become re-established 7 to 8 weeks later. Maximum benefit of the residual anthelmintic effect of closantel against H.contortus was obtained only when all sheep in the flock were treated; it took 10 weeks longer for H.contortus to form 50% of larval cultures when the whole flock was treated than when only a part of the flock was treated.
用7.5毫克/千克或15.0毫克/千克氯氰碘柳胺钠单次处理的绵羊，与未处理的绵羊一起放牧，在处理后分别至少4至5周和6至7周内未感染捻转血矛线虫。当整个羊群用15.0毫克/千克处理时，捻转血矛线虫在7至8周后开始重新出现。仅当羊群中的所有绵羊都接受处理时，才能获得氯氰碘柳胺钠对捻转血矛线虫的残留驱虫效果的最大益处；与仅处理部分羊群相比，当整个羊群都接受处理时，捻转血矛线虫形成50%幼虫培养物所需的时间要长10周。
