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一种伴有涉及BCL6、MYC和IGH的三向易位t(3;8;14)(q27;q24;q32)的双打击高级别B细胞淋巴瘤。

A double-hit High-grade B-cell lymphoma with three-way translocation t(3;8;14)(q27;q24;q32) involving BCL6, MYC, and IGH.

作者信息

De Paoli Elena, Bandiera Laura, Ravano Emanuele, Cesana Clara, Grillo Giovanni, Mancini Valentina, De Canal Gabriella, Bonoldi Emanuela, Soriani Silvia

机构信息

Department of Laboratory Medicine ASST Grande Ospedale Metropolitano Niguarda Milan Italy.

Division of Hematology ASST Grande Ospedale Metropolitano Niguarda Milan Italy.

出版信息

Clin Case Rep. 2018 Oct 26;6(12):2411-2415. doi: 10.1002/ccr3.1871. eCollection 2018 Dec.

DOI:10.1002/ccr3.1871
PMID:30564339
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6293148/
Abstract

We describe an High-grade B-cell lymphoma case, in which a complex translocation t(3;8;14) with effects on the genes BCL6, MYC, and IGH, was detected. This case could be the first double-hit lymphoma with a single chromosome rearrangement causing the double effect with three genes involved.

摘要

我们描述了一例高级别B细胞淋巴瘤病例，其中检测到一种复杂的易位t(3;8;14)，它对BCL6、MYC和IGH基因产生影响。该病例可能是首例由单一染色体重排导致三个基因受累产生双重效应的双打击淋巴瘤。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e5b9/6293148/75b687fed3de/CCR3-6-2411-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e5b9/6293148/e793e27978d9/CCR3-6-2411-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e5b9/6293148/75b687fed3de/CCR3-6-2411-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e5b9/6293148/e793e27978d9/CCR3-6-2411-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e5b9/6293148/75b687fed3de/CCR3-6-2411-g002.jpg

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2
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