Elgner Fabian, Hildt Eberhard, Bender Daniela
Department of Virology, Paul-Ehrlich-Institut, Langen, Germany.
Front Cell Dev Biol. 2018 Dec 4;6:166. doi: 10.3389/fcell.2018.00166. eCollection 2018.
Although potent direct-acting antiviral drugs for the treatment of chronic hepatitis C virus (HCV) infection are licensed, there are more than 70 million individuals suffering from chronic HCV infection. In light of the limited access to these drugs, high costs, and a lot of undiagnosed cases, it is expected that the number of HCV cases will not decrease worldwide in the next years. Therefore, and due to the paradigmatic character of HCV for deciphering the crosstalk between viral pathogens and the host cell, characterization of HCV life cycle remains a challenge. HCV belongs to the family of . As an enveloped virus HCV life cycle depends in many steps on intracellular trafficking. Rab GTPases, a large family of small GTPases, play a central role in intracellular trafficking processes controlling fusion, uncoating, vesicle budding, motility by recruiting specific effector proteins. This review describes the relevance of various Rab proteins for the different steps of the HCV life cycle.
尽管用于治疗慢性丙型肝炎病毒（HCV）感染的强效直接作用抗病毒药物已获许可，但仍有超过7000万人患有慢性HCV感染。鉴于这些药物的可及性有限、成本高昂以及大量未确诊病例，预计未来几年全球HCV病例数量不会减少。因此，由于HCV在解读病毒病原体与宿主细胞之间的相互作用方面具有典型特征，HCV生命周期的表征仍然是一项挑战。HCV属于……家族。作为一种包膜病毒，HCV的生命周期在许多步骤上依赖于细胞内运输。Rab GTP酶是小GTP酶的一个大家族，通过招募特定的效应蛋白，在控制融合、脱壳、囊泡出芽、运动的细胞内运输过程中发挥核心作用。本综述描述了各种Rab蛋白在HCV生命周期不同步骤中的相关性。
