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慢性复发性骨髓炎:外科医生的难题。

Chronic recurrent osteomyelitis: A surgeon's enigma.

机构信息

Department of Oral & Maxillofacial Surgery, Manipal College of Dental Sciences, Manipal, Karnataka, India.

Department of Oral Medicine & Radiology, Manipal College of Dental Sciences, Manipal, Karnataka, India.

出版信息

J Oral Pathol Med. 2019 Feb;48(2):180-184. doi: 10.1111/jop.12814. Epub 2019 Jan 4.

Abstract

BACKGROUND

Chronic recurrent forms of osteomyelitis of the mandible with their morbid clinical course have long been considered a challenge to maxillofacial surgeons in terms of both diagnosis and treatment. Various classifications and treatments have been established through the ages to define and manage the inflammatory symptoms occurring in adults and children. This paper discusses two such entities occurring in an adult and a child, highlighting the diagnostic and treatment challenges of recurrent osteomyelitis.

METHODS

A thorough workup which included clinical, radiographic, blood investigations was done, followed by administration of antibiotics and anti-inflammatory with or without surgical debridement/adjuvant therapies. Correlation of our findings and treatment plan was done with evidence-based literature and practice.

RESULTS

Complete resolution of symptoms with radiographic evidence was achieved in both the cases. In the recurrence period, long-term steroids, NSAIDs, antibiotics resulted in better outcomes.

CONCLUSION

The evidence-based protocol for osteomyelitis stresses on short inpatient stays predicated on efficient literature. Thorough clinical and radiographic evaluation with aggressive medical management and surgical intervention when necessary can result in longer symptom-free periods. Thus understanding the disease, recurrence pattern and response to therapy is essential.

摘要

背景

下颌骨慢性复发性骨髓炎的病程较为复杂,一直以来都是颌面外科医生在诊断和治疗方面面临的挑战。多年来,人们已经制定了各种分类和治疗方法,以定义和管理成人和儿童出现的炎症症状。本文讨论了在成人和儿童中发生的两种此类疾病,重点介绍了复发性骨髓炎的诊断和治疗挑战。

方法

我们进行了全面的检查,包括临床、影像学和血液检查,然后给予抗生素和抗炎治疗,辅以清创术和/或辅助治疗。我们将发现和治疗计划与基于证据的文献和实践进行了关联。

结果

在两种情况下,症状均完全缓解,且影像学证据显示治愈。在复发期间,长期使用类固醇、非甾体抗炎药和抗生素可获得更好的结果。

结论

骨髓炎的循证治疗方案强调基于文献的短期住院治疗。彻底的临床和影像学评估,以及积极的药物治疗和必要时的手术干预,可以延长无症状期。因此,了解疾病、复发模式和治疗反应至关重要。

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