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通过表达哺乳动物细胞色素 P450 2e1 基因的转基因室内植物,绿萝(Epipremnum aureum),极大地增强了挥发性有机致癌物的去除。

Greatly Enhanced Removal of Volatile Organic Carcinogens by a Genetically Modified Houseplant, Pothos Ivy ( Epipremnum aureum) Expressing the Mammalian Cytochrome P450 2e1 Gene.

机构信息

Department of Civil and Environmental Engineering , University of Washington , Box 355014, Seattle , Washington 98195-5014 , United States.

出版信息

Environ Sci Technol. 2019 Jan 2;53(1):325-331. doi: 10.1021/acs.est.8b04811. Epub 2018 Dec 19.

Abstract

The indoor air in urban homes of developed countries is usually contaminated with significant levels of volatile organic carcinogens (VOCs), such as formaldehyde, benzene, and chloroform. There is a need for a practical, sustainable technology for the removal of VOCs in homes. Here we show that a detoxifying transgene, mammalian cytochrome P450 2e1 can be expressed in a houseplant, Epipremnum aureum, pothos ivy, and that the resulting genetically modified plant has sufficient detoxifying activity against benzene and chloroform to suggest that biofilters using transgenic plants could remove VOCs from home air at useful rates.

摘要

发达国家城市家庭的室内空气通常受到高水平挥发性有机致癌物质(VOCs)的污染,例如甲醛、苯和三氯甲烷。因此,需要有一种实用且可持续的技术来去除家庭中的 VOCs。在这里,我们表明解毒基因,哺乳动物细胞色素 P450 2e1 可以在室内植物绿萝中表达,并且由此产生的转基因植物对苯和三氯甲烷具有足够的解毒活性,这表明使用转基因植物的生物过滤器可以以有用的速度从室内空气中去除 VOCs。

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