Department of Radiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, 90024, USA.
Physics and Biology in Medicine Graduate Program, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, 90024, USA.
Med Phys. 2019 Feb;46(2):902-912. doi: 10.1002/mp.13301. Epub 2018 Dec 21.
Size-specific dose estimates (SSDE) conversion factors have been determined by AAPM Report 204 to adjust CTDI to account for patient size but were limited to body CT examinations. The purpose of this work was to determine conversion factors that could be used for an SSDE for helical, head CT examinations for patients of different sizes.
Validated Monte Carlo (MC) simulation methods were used to estimate dose to the center of the scan volume from a routine, helical head examination for a group of patient models representing a range of ages and sizes. Ten GSF/ICRP voxelized phantom models and five pediatric voxelized patient models created from CT image data were used in this study. CT scans were simulated using a Siemens multidetector row CT equivalent source model. Scan parameters were taken from the AAPM Routine Head protocols for a fixed tube current (FTC), helical protocol, and scan lengths were adapted to the anatomy of each patient model. MC simulations were performed using mesh tallies to produce voxelized dose distributions for the entire scan volume of each model. Three tally regions were investigated: (1) a small 0.6 cc volume at the center of the scan volume, (2) 0.8-1.0 cm axial slab at the center of the scan volume, and (3) the entire scan volume. Mean dose to brain parenchyma for all three regions was calculated. Mean bone dose and a mass-weighted average dose, consisting of brain parenchyma and bone, were also calculated for the slab in the central plane and the entire scan volume. All dose measures were then normalized by CTDI for the 16 cm phantom (CTDI ). Conversion factors were determined by calculating the relationship between normalized doses and water equivalent diameter (D ).
CTDI -normalized mean brain parenchyma dose values within the 0.6 cc volume, 0.8-1.0 cm central axial slab, and the entire scan volume, when parameterized by D , had an exponential relationship with a coefficient of determination (R ) of 0.86, 0.84, and 0.88, respectively. There was no statistically significant difference between the conversion factors resulting from these three different tally regions. Exponential relationships between CTDI -normalized mean bone doses had R values of 0.83 and 0.87 for the central slab and for the entire scan volume, respectively. CTDI -normalized mass-weighted average doses had R values of 0.39 and 0.51 for the central slab and for the entire scan volume, respectively.
Conversion factors that describe the exponential relationship between CTDI -normalized mean brain dose and a size metric (D ) for helical head CT examinations have been reported for two different interpretations of the center of the scan volume. These dose descriptors have been extended to describe the dose to bone in the center of the scan volume as well as a mass-weighted average dose to brain and bone. These may be used, when combined with other efforts, to develop an SSDE dose coefficients for routine, helical head CT examinations.
AAPM 报告 204 确定了大小特异性剂量估计(SSDE)转换因子,以调整 CTDI 以考虑患者大小,但仅限于身体 CT 检查。本研究的目的是确定可用于不同大小患者螺旋头部 CT 检查的 SSDE 的转换因子。
使用经过验证的蒙特卡罗(MC)模拟方法,从一组代表不同年龄和体型的患者模型的常规螺旋头部 CT 检查中估算扫描体积中心的剂量。本研究使用了 10 个 GSF/ICRP 体素化体模和 5 个从 CT 图像数据创建的儿科体素化患者模型。使用西门子多排 CT 等效源模型模拟 CT 扫描。扫描参数取自 AAPM 常规头部协议,用于固定管电流(FTC)、螺旋协议,并且扫描长度适应每个患者模型的解剖结构。使用网格总和进行 MC 模拟,以生成每个模型整个扫描体积的体素化剂量分布。研究了三个计数区域:(1)扫描体积中心的小 0.6cc 体积,(2)扫描体积中心的 0.8-1.0cm 轴向薄片,以及(3)整个扫描体积。为所有三个区域计算了脑实质的平均剂量。还计算了中央平面上的薄片和整个扫描体积的骨剂量和质量加权平均剂量(由脑实质和骨组成)。然后,通过将 CTDI 除以 16cm 体模(CTDI )来归一化所有剂量测量值。通过计算归一化剂量与水当量直径(D)之间的关系来确定转换因子。
当参数化为 D 时,0.6cc 体积、0.8-1.0cm 中心轴向薄片和整个扫描体积内的 CTDI 归一化平均脑实质剂量值与指数关系具有 0.86、0.84 和 0.88 的决定系数(R)。这三个不同计数区域得出的转换因子之间没有统计学上的显著差异。中央薄片和整个扫描体积的 CTDI 归一化平均骨剂量的指数关系的 R 值分别为 0.83 和 0.87。中央薄片和整个扫描体积的 CTDI 归一化质量加权平均剂量的 R 值分别为 0.39 和 0.51。
已经为两种不同的扫描体积中心解释报告了描述 CTDI 归一化平均脑剂量与大小度量(D)之间指数关系的转换因子,这些剂量描述符已扩展到描述扫描体积中心的骨剂量以及脑和骨的质量加权平均剂量。当与其他努力相结合时,这些可以用于开发常规螺旋头部 CT 检查的 SSDE 剂量系数。