Institute for Research in Biomedicine, Università della Svizzera italiana, 6500 Bellinzona, Switzerland; email:
Radcliffe Department of Medicine, University of Oxford, Oxford OX3 9DU, United Kingdom.
Annu Rev Immunol. 2019 Apr 26;37:225-246. doi: 10.1146/annurev-immunol-042617-053301. Epub 2018 Dec 19.
remains a serious public health problem and a continuous challenge for the immune system due to the complexity and diversity of the pathogen. Recent advances from several laboratories in the characterization of the antibody response to the parasite have led to the identification of critical targets for protection and revealed a new mechanism of diversification based on the insertion of host receptors into immunoglobulin genes, leading to the production of receptor-based antibodies. These advances have opened new possibilities for vaccine design and passive antibody therapies to provide sterilizing immunity and control blood-stage parasites.
寄生虫感染仍然是一个严重的公共卫生问题，也是免疫系统面临的持续挑战，这是由于病原体的复杂性和多样性所致。最近，几个实验室在对寄生虫的抗体反应进行特征描述方面取得了进展，这有助于鉴定出保护性的关键靶标，并揭示了一种基于将宿主受体插入免疫球蛋白基因的多样化新机制，从而产生基于受体的抗体。这些进展为疫苗设计和被动抗体疗法提供了新的可能性，以提供杀菌性免疫和控制血液阶段寄生虫。
