• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
RNA interference screen identifies NAA10 as a regulator of PXR transcription.RNA 干扰筛选鉴定 NAA10 为 PXR 转录的调节剂。
Biochem Pharmacol. 2019 Feb;160:92-109. doi: 10.1016/j.bcp.2018.12.012. Epub 2018 Dec 16.
2
N-α-acetyltransferase 10 (NAA10) in development: the role of NAA10.N-α-乙酰转移酶 10（NAA10）在发育中的作用：NAA10 的作用。
Exp Mol Med. 2018 Jul 27;50(7):1-11. doi: 10.1038/s12276-018-0105-2.
3
microRNA-342-5p and miR-608 inhibit colon cancer tumorigenesis by targeting NAA10.微小RNA-342-5p和miR-608通过靶向NAA10抑制结肠癌肿瘤发生。
Oncotarget. 2016 Jan 19;7(3):2709-20. doi: 10.18632/oncotarget.6458.
4
Hydroxylation of the Acetyltransferase NAA10 Trp38 Is Not an Enzyme-Switch in Human Cells.乙酰转移酶 NAA10 的色氨酸 38 位羟化不是人细胞中的酶开关。
Int J Mol Sci. 2021 Oct 30;22(21):11805. doi: 10.3390/ijms222111805.
5
Transcriptional and post-transcriptional regulation of the pregnane X receptor: a rationale for interindividual variability in drug metabolism.孕烷X受体的转录和转录后调控：药物代谢个体间差异的一个理论依据。
Arch Toxicol. 2021 Jan;95(1):11-25. doi: 10.1007/s00204-020-02916-x. Epub 2020 Nov 9.
6
A novel NAA10 variant with impaired acetyltransferase activity causes developmental delay, intellectual disability, and hypertrophic cardiomyopathy.一种新型 NAA10 变异体，其乙酰转移酶活性受损，导致发育迟缓、智力残疾和肥厚型心肌病。
Eur J Hum Genet. 2018 Sep;26(9):1294-1305. doi: 10.1038/s41431-018-0136-0. Epub 2018 May 10.
7
Characterization of Lysine Acetyltransferase Activity of Recombinant Human ARD1/NAA10.鉴定重组人 ARD1/NAA10 的赖氨酸乙酰转移酶活性。
Molecules. 2020 Jan 29;25(3):588. doi: 10.3390/molecules25030588.
8
NAA10-related syndrome.NAA10 相关综合征。
Exp Mol Med. 2018 Jul 27;50(7):1-10. doi: 10.1038/s12276-018-0098-x.
9
compensates for in mice in the amino-terminal acetylation pathway.补偿了氨基酸 N 端乙酰化途径中突变的小鼠。
Elife. 2021 Aug 6;10:e65952. doi: 10.7554/eLife.65952.
10
A comprehensive evaluation of anti-diabetic drugs on nuclear receptor PXR platform.抗糖尿病药物在核受体 PXR 平台上的综合评价。
Toxicol In Vitro. 2019 Oct;60:347-358. doi: 10.1016/j.tiv.2019.06.015. Epub 2019 Jun 21.

引用本文的文献

1
Targeting pregnane X receptor with a potent agonist-based PROTAC to delay colon cancer relapse.用基于强效激动剂的PROTAC靶向孕烷X受体以延缓结肠癌复发。
Oncogenesis. 2025 Aug 30;14(1):34. doi: 10.1038/s41389-025-00573-2.
2
Bile Acids and Microbiota Interplay in Pancreatic Cancer.胰腺癌中胆汁酸与微生物群的相互作用
Cancers (Basel). 2023 Jul 11;15(14):3573. doi: 10.3390/cancers15143573.
3
DUOX2 As a Potential Prognostic Marker which Promotes Cell Motility and Proliferation in Pancreatic Cancer.双氧化酶 2 作为一种潜在的预后标志物，促进胰腺癌中的细胞迁移和增殖。
Biomed Res Int. 2021 Mar 2;2021:6530298. doi: 10.1155/2021/6530298. eCollection 2021.
4
The influence of the long-term chemical activation of the nuclear receptor pregnane X receptor (PXR) on liver carcinogenesis in mice.长期化学激活核受体孕烷 X 受体 (PXR) 对小鼠肝脏癌变的影响。
Arch Toxicol. 2021 Mar;95(3):1089-1102. doi: 10.1007/s00204-020-02955-4. Epub 2021 Jan 4.
5
Transcriptional and post-transcriptional regulation of the pregnane X receptor: a rationale for interindividual variability in drug metabolism.孕烷X受体的转录和转录后调控：药物代谢个体间差异的一个理论依据。
Arch Toxicol. 2021 Jan;95(1):11-25. doi: 10.1007/s00204-020-02916-x. Epub 2020 Nov 9.
6
Regulation of CAR and PXR Expression in Health and Disease.调节 CAR 和 PXR 在健康和疾病中的表达。
Cells. 2020 Oct 31;9(11):2395. doi: 10.3390/cells9112395.
7
PXR: a center of transcriptional regulation in cancer.孕烷X受体：癌症转录调控的核心
Acta Pharm Sin B. 2020 Feb;10(2):197-206. doi: 10.1016/j.apsb.2019.06.012. Epub 2019 Jun 29.

本文引用的文献

1
A proximity-tagging system to identify membrane protein-protein interactions.一种用于识别膜蛋白-蛋白相互作用的临近标记系统。
Nat Methods. 2018 Sep;15(9):715-722. doi: 10.1038/s41592-018-0100-5. Epub 2018 Aug 13.
2
PXR: More Than Just a Master Xenobiotic Receptor.PXR：不仅仅是一个主要的外源性受体。
Mol Pharmacol. 2018 Feb;93(2):119-127. doi: 10.1124/mol.117.110155. Epub 2017 Nov 7.
3
A Molecular Aspect in the Regulation of Drug Metabolism: Does PXR-Induced Enzyme Expression Always Lead to Functional Changes in Drug Metabolism?药物代谢调控中的分子层面：孕烷X受体诱导的酶表达是否总能导致药物代谢的功能变化？
Curr Pharmacol Rep. 2016 Aug;2(4):187-192. doi: 10.1007/s40495-016-0062-1. Epub 2016 May 4.
4
Pregnane X Receptor and Cancer: Context-Specificity is Key.孕烷X受体与癌症：上下文特异性是关键。
Nucl Receptor Res. 2016 Jun 12;3. doi: 10.11131/2016/101198.
5
Human pregnane X receptor compromises the function of p53 and promotes malignant transformation.人妊娠相关 X 受体（pregnane X receptor，PXR）可损害 p53 功能并促进恶性转化。
Cell Death Discov. 2016 Apr 18;2:16023. doi: 10.1038/cddiscovery.2016.23. eCollection 2016.
6
Co-expression of pregnane X receptor and ATP-binding cassette sub-family B member 1 in peripheral blood: A prospective indicator for drug resistance prediction in non-small cell lung cancer.孕烷X受体与ATP结合盒转运体B家族成员1在外周血中的共表达：非小细胞肺癌耐药预测的前瞻性指标
Oncol Lett. 2016 May;11(5):3033-3039. doi: 10.3892/ol.2016.4369. Epub 2016 Mar 22.
7
Tryptophan 299 is a conserved residue of human pregnane X receptor critical for the functional consequence of ligand binding.色氨酸299是人类孕烷X受体的一个保守残基，对配体结合的功能后果至关重要。
Biochem Pharmacol. 2016 Mar 15;104:131-8. doi: 10.1016/j.bcp.2016.02.009. Epub 2016 Feb 18.
8
CYP3A5 mediates basal and acquired therapy resistance in different subtypes of pancreatic ductal adenocarcinoma.细胞色素P450 3A5（CYP3A5）介导不同亚型胰腺导管腺癌的基础和获得性治疗耐药性。
Nat Med. 2016 Mar;22(3):278-87. doi: 10.1038/nm.4038. Epub 2016 Feb 8.
9
Molecular basis of contact inhibition of locomotion.运动接触抑制的分子基础。
Cell Mol Life Sci. 2016 Mar;73(6):1119-30. doi: 10.1007/s00018-015-2090-0. Epub 2015 Nov 19.
10
The biological functions of Naa10 - From amino-terminal acetylation to human disease.Naa10的生物学功能——从氨基末端乙酰化到人类疾病
Gene. 2015 Aug 10;567(2):103-31. doi: 10.1016/j.gene.2015.04.085. Epub 2015 May 16.

RNA 干扰筛选鉴定 NAA10 为 PXR 转录的调节剂。

RNA interference screen identifies NAA10 as a regulator of PXR transcription.

机构信息

Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN 38105, United States.

Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN 38105, United States; Integrated Biomedical Sciences Program, University of Tennessee Health Science Center, Memphis, TN 38163, United States.

出版信息

Biochem Pharmacol. 2019 Feb;160:92-109. doi: 10.1016/j.bcp.2018.12.012. Epub 2018 Dec 16.

DOI:10.1016/j.bcp.2018.12.012
PMID:30566892
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6361121/
Abstract

The pregnane X receptor (PXR) is a principal xenobiotic receptor crucial in the detection, detoxification, and clearance of toxic substances from the body. PXR plays a vital role in the metabolism and disposition of drugs, and elevated PXR levels contribute to cancer drug resistance. Therefore, to modulate PXR activity and mitigate drug resistance, it is imperative to fully understand its regulation. To this end, we screened a transcription factor siRNA library in pancreatic cancer cells that express high levels of PXR. Through a comprehensive deconvolution process, we identified N-alpha-acetyltransferase 10 (NAA10) as a factor in the transcriptional machinery regulating PXR transcription. Because no one single factor has 100% operational control of PXR transcriptional regulation, our results together with other previous findings suggest that the transcriptional regulation of PXR is complex and that multiple factors contribute to the process including NAA10.

摘要

pregnane X 受体 (PXR) 是一种重要的外源性受体，在检测、解毒和清除体内有害物质方面起着关键作用。PXR 在药物的代谢和处置中起着至关重要的作用，而 PXR 水平的升高导致癌症药物耐药性。因此，为了调节 PXR 的活性和减轻耐药性，必须充分了解其调节机制。为此，我们在表达高水平 PXR 的胰腺癌细胞中筛选了转录因子 siRNA 文库。通过一个全面的反卷积过程，我们鉴定出 N-alpha-乙酰基转移酶 10 (NAA10) 是调节 PXR 转录的转录机制中的一个因素。由于没有一个单一的因素对 PXR 转录调控有 100%的操作控制，我们的结果与其他先前的发现一起表明，PXR 的转录调控是复杂的，包括 NAA10 在内的多个因素参与了这一过程。