霍奇金淋巴瘤斗篷野放射治疗后迟发性垂头综合征
Late onset of dropped head syndrome following mantle radiation therapy for Hodgkin lymphoma.
作者信息
Di Stefano Vincenzo, Attanasi Carmine, Ferrante Camilla, Di Muzio Antonio
机构信息
Department of Neuroscience, Imaging and Clinical sciences, "G. d' Annunzio" University, Chieti, Italy.
Centro regionale Sant'Alessio - "Margherita di Savoia per i ciechi", Roma, Italy.
出版信息
BMJ Case Rep. 2018 Dec 14;11(1):e226822. doi: 10.1136/bcr-2018-226822.
Abstract
Dropped head syndrome (DHS) is a rare condition, characterised by weakness of the cervical paraspinal muscles with sagging of the head. It is usually seen in association with neurological disorders and rarely can follow radiotherapy. We report a case of a 54-year-old man survivor of Hodgkin lymphoma (HL), who developed DHS 28 years after radiotherapy. He was referred to our department due to progressive weakness and atrophy of cervical paraspinal and shoulder girdle musculature. Physical and neurophysiological examination, electromyography and MRI confirmed the diagnosis of DHS. In the following years, there was no progression of symptoms.
摘要
低头综合征（DHS）是一种罕见疾病，其特征为颈段椎旁肌无力伴头部下垂。它通常与神经系统疾病相关，很少继发于放疗后。我们报告一例54岁男性霍奇金淋巴瘤（HL）幸存者，其在放疗28年后出现了低头综合征。由于颈段椎旁和肩胛带肌肉组织进行性无力和萎缩，他被转诊至我们科室。体格检查、神经生理学检查、肌电图检查及磁共振成像（MRI）均确诊为低头综合征。在随后几年中，症状未进展。
相似文献
1
Late onset of dropped head syndrome following mantle radiation therapy for Hodgkin lymphoma.霍奇金淋巴瘤斗篷野放射治疗后迟发性垂头综合征
BMJ Case Rep. 2018 Dec 14;11(1):e226822. doi: 10.1136/bcr-2018-226822.
2
[A survivor of Hodgkin lymphoma manifesting dropped head syndrome as a late-onset complication of radiotherapy: a case report].[一名霍奇金淋巴瘤幸存者表现为放疗迟发性并发症垂头综合征：病例报告]
Rinsho Shinkeigaku. 2018 May 25;58(5):308-313. doi: 10.5692/clinicalneurol.cn-001158. Epub 2018 Apr 28.
3
Late appearance of dropped head syndrome after radiotherapy for Hodgkin's disease.霍奇金淋巴瘤放疗后迟发性垂头综合征的出现
Muscle Nerve. 2006 Nov;34(5):666-9. doi: 10.1002/mus.20623.
4
Radiation-induced camptocormia and dropped head syndrome: Review and case report of radiation-induced movement disorders.放射性脊髓病和垂头综合征：放射性运动障碍的综述与病例报告
Strahlenther Onkol. 2015 Oct;191(10):765-70. doi: 10.1007/s00066-015-0857-8. Epub 2015 Jun 14.
5
Late-onset cervicoscapular muscle atrophy and weakness after radiotherapy for Hodgkin disease: a case series.霍奇金病放疗后迟发性颈肩肌无力和萎缩：病例系列。
J Neurol Neurosurg Psychiatry. 2010 Jan;81(1):101-4. doi: 10.1136/jnnp.2008.167577.
6
[Dropped Head Syndrome after whiplash injury in a patient treated for a Hodgkin's lymphoma by mantle field radiotherapy].[一名接受斗篷野放疗治疗霍奇金淋巴瘤的患者在挥鞭样损伤后出现垂头综合征]
Cancer Radiother. 2013 Feb;17(1):44-9. doi: 10.1016/j.canrad.2012.10.010. Epub 2012 Dec 4.
7
Early onset of bilateral brachial plexopathy during mantle radiotherapy for Hodgkin's disease.霍奇金病斗篷野放疗期间双侧臂丛神经病变的早期发生
Clin Oncol (R Coll Radiol). 2000;12(5):289-91. doi: 10.1053/clon.2000.9175.
8
Progressive muscle atrophy and weakness after treatment by mantle field radiotherapy in Hodgkin lymphoma survivors.霍奇金淋巴瘤幸存者接受斗篷野放射治疗后出现进行性肌肉萎缩和无力。
Int J Radiat Oncol Biol Phys. 2012 Feb 1;82(2):612-8. doi: 10.1016/j.ijrobp.2010.11.064. Epub 2011 Feb 1.
9
Testosterone Therapy for Dropped Head Syndrome: A Case Report.睾酮治疗垂头综合征：病例报告。
J Clin Neuromuscul Dis. 2022 Dec 1;24(2):98-102. doi: 10.1097/CND.0000000000000372.
10
The Role of the Headmaster Collar (Cervical) for Dropped Head Syndrome in Hodgkin Lymphoma Survivors.校长领（颈部）在霍奇金淋巴瘤幸存者垂头综合征中的作用
PM R. 2019 Sep;11(9):939-943. doi: 10.1002/pmrj.12010. Epub 2019 Feb 22.
引用本文的文献
1
Outcomes of Conservative Versus Surgical Treatment of Dropped Head Syndrome in a Single Institution: A Case Series and Review of the Literature.单机构中头下垂综合征保守治疗与手术治疗的疗效：病例系列及文献综述
Cureus. 2025 Mar 18;17(3):e80777. doi: 10.7759/cureus.80777. eCollection 2025 Mar.
2
Proposal of a diagnostic algorithm for radiation-induced dropped head syndrome in long-term childhood cancer survivors based on a prospective study in a specialized clinical setting and a review of the literature.基于专门临床环境中的前瞻性研究和文献复习，提出一种用于诊断长期儿童癌症幸存者放射性垂头综合征的诊断算法。
J Cancer Res Clin Oncol. 2023 Dec;149(20):17865-17879. doi: 10.1007/s00432-023-05480-w. Epub 2023 Nov 10.
3
Dropped head syndrome due to chemoradiotherapy for nasal lymphoma, characterised by short tau inversion recovery high signal intensity in the cervical paraspinal muscles.鼻腔淋巴瘤放化疗后所致垂头综合征，其特征为颈部椎旁肌肉在短tau反转恢复序列上呈高信号强度。
BMJ Case Rep. 2022 Nov 11;15(11):e252446. doi: 10.1136/bcr-2022-252446.
4
Early-Onset Dropped Head Syndrome and Person-in-the-Barrel Syndrome After Radiation Therapy: Clinical, Electromyographic, and MRI Findings.放射治疗后早发性垂头综合征和桶中人综合征：临床、肌电图及磁共振成像结果
Cureus. 2022 Aug 22;14(8):e28279. doi: 10.7759/cureus.28279. eCollection 2022 Aug.
5
The Short and Intensive Rehabilitation (SHAiR) Program Improves Dropped Head Syndrome Caused by Amyotrophic Lateral Sclerosis: A Case Report.《短程强化康复（SHAiR）方案改善肌萎缩侧索硬化所致垂头综合征：病例报告》。
Medicina (Kaunas). 2022 Mar 21;58(3):452. doi: 10.3390/medicina58030452.
本文引用的文献
1
[A survivor of Hodgkin lymphoma manifesting dropped head syndrome as a late-onset complication of radiotherapy: a case report].[一名霍奇金淋巴瘤幸存者表现为放疗迟发性并发症垂头综合征：病例报告]
Rinsho Shinkeigaku. 2018 May 25;58(5):308-313. doi: 10.5692/clinicalneurol.cn-001158. Epub 2018 Apr 28.
2
Dropped Head Syndrome Following Mantle Radiation Therapy.斗篷野放射治疗后垂头综合征
Intern Med. 2016;55(4):421-2. doi: 10.2169/internalmedicine.55.5579. Epub 2016 Feb 15.
3
Dropped head syndrome: diagnosis and management.低头综合征：诊断与管理
Evid Based Spine Care J. 2011 May;2(2):41-7. doi: 10.1055/s-0030-1267104.
4
[Dropped Head Syndrome after whiplash injury in a patient treated for a Hodgkin's lymphoma by mantle field radiotherapy].[一名接受斗篷野放疗治疗霍奇金淋巴瘤的患者在挥鞭样损伤后出现垂头综合征]
Cancer Radiother. 2013 Feb;17(1):44-9. doi: 10.1016/j.canrad.2012.10.010. Epub 2012 Dec 4.
5
Dropped head syndrome: etiology and management.垂头综合征：病因与治疗。
J Am Acad Orthop Surg. 2012 Dec;20(12):766-74. doi: 10.5435/JAAOS-20-12-766.
6
Dropped head syndrome induced by chemoradiotherapy for nasopharyngeal carcinoma: a case report.放化疗致鼻咽癌后 Dropped head 综合征 1 例报告
Jpn J Clin Oncol. 2012 Nov;42(11):1091-3. doi: 10.1093/jjco/hys135. Epub 2012 Aug 22.
7
Late-onset cervicoscapular muscle atrophy and weakness after radiotherapy for Hodgkin disease: a case series.霍奇金病放疗后迟发性颈肩肌无力和萎缩：病例系列。
J Neurol Neurosurg Psychiatry. 2010 Jan;81(1):101-4. doi: 10.1136/jnnp.2008.167577.
8
Dropped-head syndrome due to high-dose irradiation.高剂量放疗所致垂头综合征
J Rheumatol. 2009 Oct;36(10):2316. doi: 10.3899/jrheum.090175.
9
Late appearance of dropped head syndrome after radiotherapy for Hodgkin's disease.霍奇金淋巴瘤放疗后迟发性垂头综合征的出现
Muscle Nerve. 2006 Nov;34(5):666-9. doi: 10.1002/mus.20623.
10
The dropped head sign in parkinsonism.帕金森病中的垂头征。
J Neurol Sci. 1999 Aug 1;167(1):22-5. doi: 10.1016/s0022-510x(99)00129-x.
Zotero 插件