心脏转甲状腺素蛋白淀粉样变性的前沿放射性核素成像
State-of-the-art radionuclide imaging in cardiac transthyretin amyloidosis.
作者信息
Singh Vasvi, Falk Rodney, Di Carli Marcelo F, Kijewski Marie, Rapezzi Claudio, Dorbala Sharmila
机构信息
Division of Nuclear Medicine and Department of Radiology, Brigham and Women's Hospital, Boston, MA, 2115, USA.
Cardiac Amyloidosis Program, Brigham and Women's Hospital, Boston, MA, 2115, USA.
出版信息
J Nucl Cardiol. 2019 Feb;26(1):158-173. doi: 10.1007/s12350-018-01552-4. Epub 2018 Dec 19.
Abstract
Cardiac amyloidosis, once considered untreatable, is now gaining well-deserved attention due to advances in imaging and the recent approval of targeted breakthrough therapies. In this paper, we discuss the role of radionuclide imaging in the evaluation and management of patients with the most common form of amyloidosis-cardiac transthyretin amyloidosis (ATTR). We provide a comprehensive summary of the literature interspersed with our institutional experience as appropriate, to deliver our perspective.
摘要
心脏淀粉样变性，曾被认为无法治疗，如今由于成像技术的进步以及近期靶向突破性疗法的获批，正获得应有的关注。在本文中，我们讨论放射性核素成像在评估和管理最常见的淀粉样变性形式——心脏转甲状腺素蛋白淀粉样变性（ATTR）患者中的作用。我们穿插适当的机构经验，对文献进行全面总结，以阐述我们的观点。
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Tafamidis Treatment for Patients with Transthyretin Amyloid Cardiomyopathy.特发性甲状腺素运载蛋白淀粉样变心肌病患者的塔法米迪治疗。
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Patisiran, an RNAi Therapeutic, for Hereditary Transthyretin Amyloidosis.用于遗传性转甲状腺素蛋白淀粉样变性的 RNAi 治疗药物 Patisiran
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