Department of Neonatology, University Hospital Motol, Second Faculty of Medicine, Charles University, Prague, Czech Republic.
Faculty of Transportation Science, Czech Technical University, Prague, Czech Republic.
J Matern Fetal Neonatal Med. 2020 Jun;33(11):1889-1894. doi: 10.1080/14767058.2018.1533941. Epub 2018 Dec 20.
To assess the plausibility of using the continuous glucose monitoring as a sole source of data for the screening of the neonatal hypoglycemia. Infants of mothers with diabetes were screened for neonatal hypoglycemia (less than 2.5 mmol/l after 4 h of life). Initial measurement was performed using point of care analyzer. We applied continuous glucose monitoring system subsequently. Infants were monitored up to 5 days or until discharge. Out of 32 infants 11 had postnatal hypoglycemia resolved within 12 h of life. Two infants had hypoglycemia found due to continuous glucose monitoring after 24 h of life when sufficient feeding was established and they did not show any signs of hypoglycemia. We did not have any false negative measurements. No infant showed clinical signs of neonatal hypoglycemia. Continuous glucose monitoring is plausible and safe to use for screening of neonatal hypoglycemia. It operates well within the range that is accepted as safe for neurodevelopment. In addition, it can be used after first day of life where regular screening ends. Limitation of this method is possible alarm negligence of caregivers.
为评估连续血糖监测是否可作为新生儿低血糖筛查的唯一数据源,我们对患有糖尿病的母亲所生婴儿进行了新生儿低血糖(生后 4 小时血糖<2.5mmol/L)筛查。初始测量采用即时检测分析仪进行。随后,我们应用了连续血糖监测系统。婴儿监测时间最长达 5 天或直至出院。在 32 例婴儿中,有 11 例于生后 12 小时内血糖恢复正常。有 2 例婴儿在生后 24 小时血糖恢复正常后,由于连续血糖监测发现低血糖,此时已建立充足喂养,且他们并未出现任何低血糖迹象。我们没有出现任何假阴性测量结果。没有婴儿出现新生儿低血糖的临床症状。连续血糖监测用于新生儿低血糖筛查是合理且安全的。它在被接受为神经发育安全范围内的操作良好。此外,它可在常规筛查结束后的生后第一天使用。该方法的局限性可能是看护者对报警的疏忽。