Miller R R, Jick H
Am J Med Sci. 1977 Nov-Dec;274(3):271-9. doi: 10.1097/00000441-197711000-00005.
Among 2,391 recipients of plain aspirin tablets, 121 (5.1%) were reported to have adverse reactions. Minor gastrointestinal disturbances, particularly heartburn and nausea, were most common (2.1%). Central nervous system effects were second (1.2%). Among these, tinnitus was reported most often (0.8%); deafness occurred in eight patients (0.3%). Gastrointestinal bleeding, the third major category of adverse reactions, occurred in 1.0% of recipients; it was not considered serious in any of the patients with reactions judged "definitely" or "probably" related to aspirin. The frequency of all adverse reactions increased as the unit dose, daily dose and total dose became larger. Deafness occurred only at high doses. Reactions were more common in females.
在2391名服用普通阿司匹林片的受试者中，有121人（5.1%）报告出现了不良反应。轻微的胃肠道不适，尤其是烧心和恶心最为常见（2.1%）。中枢神经系统影响次之（1.2%）。其中，耳鸣报告最为频繁（0.8%）；8名患者出现耳聋（0.3%）。胃肠道出血是第三大类不良反应，发生在1.0%的受试者中；在所有被判定“肯定”或“可能”与阿司匹林有关的不良反应患者中，均未被视为严重情况。所有不良反应的发生率随着单位剂量、日剂量和总剂量的增加而升高。耳聋仅在高剂量时出现。不良反应在女性中更为常见。
