Reproductive Center, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing 100026, China.
Department of Clinical Laboratory, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing 100026, China.
J Environ Sci (China). 2019 Mar;77:210-217. doi: 10.1016/j.jes.2018.07.015. Epub 2018 Aug 22.
Recent research indicates that the human infertility rate is increasing. Although various reasons have been hypothesized for the growing infertility rate, environmental contaminants are potentially important causal agents associated with this change. Chemical contaminants are widespread throughout our environment and human exposure is virtually unavoidable. The overall contribution of environmental exposure to infertility is unknown, but studies involving occupational exposure, together with results from animal experiments, suggest that environmental contaminants may adversely affect fertility. We reviewed the adverse effects of environmental exposure on fertility and related reproductive outcomes. Environmental contaminants covered in this review include heavy metals, organic solvents, pesticides and endocrine disrupting chemicals. It is hoped that this review will highlight the need for further research in this area.
最近的研究表明，人类不孕不育率正在上升。尽管人们对不断上升的不孕不育率提出了各种假设，但环境污染物可能是导致这一变化的重要原因。化学污染物在我们的环境中广泛存在，人类几乎无法避免接触。环境暴露对不孕不育的总体影响尚不清楚，但涉及职业暴露的研究以及动物实验的结果表明，环境污染物可能对生育能力产生不利影响。我们综述了环境暴露对生育能力和相关生殖结果的不良影响。本综述涵盖的环境污染物包括重金属、有机溶剂、农药和内分泌干扰化学物质。希望这篇综述能强调在这一领域进一步研究的必要性。
