靶向 NAD 代谢以增强放射治疗反应。
Targeting NAD Metabolism to Enhance Radiation Therapy Responses.
机构信息
The Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA.
Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN.
出版信息
Semin Radiat Oncol. 2019 Jan;29(1):6-15. doi: 10.1016/j.semradonc.2018.10.009.
Abstract
Nicotinamide adenine dinucleotide (NAD) metabolism is integrally connected with the mechanisms of action of radiation therapy and is altered in many radiation-resistant tumors. This makes NAD metabolism an ideal target for therapies that increase radiation sensitivity and improve patient outcomes. This review provides an overview of NAD metabolism in the context of the cellular response to ionizing radiation, as well as current therapies that target NAD metabolism to enhance radiation therapy responses. Additionally, we summarize state-of-the-art methods for measuring, modeling, and manipulating NAD metabolism, which are being used to identify novel targets in the NAD metabolic network for therapeutic interventions in combination with radiation therapy.
摘要
烟酰胺腺嘌呤二核苷酸（NAD）代谢与放射治疗的作用机制密切相关，并且在许多放射抗性肿瘤中发生改变。这使得 NAD 代谢成为增加辐射敏感性和改善患者预后的理想治疗靶标。本综述概述了 NAD 代谢在细胞对电离辐射的反应中的作用，以及目前靶向 NAD 代谢以增强放射治疗反应的治疗方法。此外，我们总结了用于测量、建模和操纵 NAD 代谢的最新方法，这些方法正在被用于鉴定 NAD 代谢网络中的新靶标，以与放射治疗联合进行治疗干预。
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