Centre for Advanced Optoelectronic Functional Materials Research, Key Laboratory for UV Light-Emitting Materials and Technology of Ministry of Education, Northeast Normal University, Changchun 130024, China.
Centre for Advanced Optoelectronic Functional Materials Research, Key Laboratory for UV Light-Emitting Materials and Technology of Ministry of Education, Northeast Normal University, Changchun 130024, China.
Mater Sci Eng C Mater Biol Appl. 2019 Feb 1;95:11-18. doi: 10.1016/j.msec.2018.10.060. Epub 2018 Oct 16.
Cancer is one of the major causes of mortality worldwide. Therefore, it is necessary to provide an effective method of tumor therapy. Herein, we designed a new type of composite particle, apoferritin (APO) encapsulated doxorubicin (DOX), and the surface of APO was modified with Au nanoshell. As a nanocarrier, APO can carry chemotherapy drug DOX (APODOX) and release drug under acidic and high temperature conditions to reduce side effects of anticancer drugs. After covering Au nanoshell (APODOX-Au), the photothermal effect can be produced because of the unique surface plasmon resonance properties of gold nanoshell. This nanoplatform also provides the multi-stimuli responsive drug release system, which can achieve drug release in different conditions and have great potential in biomedical applications. Our investigation has demonstrated that APODOX-Au has good stability, high dispersibility and biocompatibility in vitro. The strong near-infrared absorption and good photothermal effect make sure the quick response to environmental changes (pH, temperature) to achieve drug release. These findings indicate that these nanoparticles have a potential application value in cancer treatment.
癌症是全球主要死亡原因之一。因此，有必要提供一种有效的肿瘤治疗方法。在此，我们设计了一种新型复合粒子，即脱铁铁蛋白（APO）包裹阿霉素（DOX），并在 APO 表面修饰金纳米壳。作为纳米载体，APO 可以携带化疗药物 DOX（APODOX），并在酸性和高温条件下释放药物，以减少抗癌药物的副作用。覆盖 Au 纳米壳（APODOX-Au）后，由于金纳米壳的独特表面等离子体共振特性，可以产生光热效应。这种纳米平台还提供了多刺激响应的药物释放系统，可以在不同条件下实现药物释放，在生物医学应用中具有巨大的潜力。我们的研究表明，APODOX-Au 在体外具有良好的稳定性、高分散性和生物相容性。强近红外吸收和良好的光热效应确保了对环境变化（pH 值、温度）的快速响应，从而实现药物释放。这些发现表明，这些纳米粒子在癌症治疗中有潜在的应用价值。
