Centre for Energy Research, H-1121 Konkoly-Thege str. 29-33, Budapest, Hungary.
Laboratory of Preclinical and Surgical Studies, Rizzoli Orthopaedic Institute, via di Barbiano 1/10, 40136 Bologna, Italy; Department of Medical and Surgical Science, University of Bologna, via G. Massarenti 9, 40138 Bologna, Italy.
Mater Sci Eng C Mater Biol Appl. 2019 Feb 1;95:381-388. doi: 10.1016/j.msec.2018.01.010. Epub 2018 Jan 31.
Multi-ions doped bioactive calcium phosphate (dCaP) layers were developed by pulse current deposition onto surgical grade titanium alloy material (Ti6Al4V). The coatings were electrodeposited from base electrolyte containing adequate amounts of calcium nitrate and ammonium dihydrogen phosphate at 70 °C. After electrodeposition, the pure CaP layers were doped with different ions that possess bioactive and antimicrobial properties, such as Zn, Mg, Sr and Ag ions. The morphology and structure of coatings were characterized by Scanning Electron Microscopy (SEM), Transmission Electron Microscopy (TEM), Energy-dispersive X-ray Spectroscopy (EDX) as well as XRD and FT-IR measurements. The results revealed the pulse current deposited and surface post-treated CaP layer to be mainly in hydroxyapatite phase. The corrosion properties of bioceramic coatings were assessed in conventional simulated body fluid (SBF) in a three electrode open cell by using potentiodynamic polarization measurements over two weeks period. The electrochemical results revealed that the pure calcium phosphate (CaP) coated implant material and the bare implant possess the highest resistivity to corrosion, while the modified calcium phosphate coating showed lower corrosion resistance by at least one order of magnitude. The cell viability measurements showed that the electrochemically deposited CaP layer was biocompatible.
多离子掺杂生物活性磷酸钙（dCaP）层通过脉冲电流沉积在外科级钛合金材料（Ti6Al4V）上制备而成。涂层通过在 70°C 时从含有足够量硝酸钙和磷酸二氢铵的基础电解液中电沉积而成。电沉积后，纯 CaP 层被掺杂了具有生物活性和抗菌性能的不同离子，如 Zn、Mg、Sr 和 Ag 离子。通过扫描电子显微镜 (SEM)、透射电子显微镜 (TEM)、能谱 (EDX) 以及 XRD 和 FT-IR 测量对涂层的形貌和结构进行了表征。结果表明，脉冲电流沉积和表面后处理的 CaP 层主要为羟基磷灰石相。通过在两周的时间内使用三电极开路池中的动电位极化测量，在常规模拟体液 (SBF) 中评估了生物陶瓷涂层的腐蚀性能。电化学结果表明，纯磷酸钙（CaP）涂层植入材料和裸植入材料对腐蚀的电阻率最高，而改性磷酸钙涂层的腐蚀电阻至少低一个数量级。细胞活力测量表明，电化学沉积的 CaP 层是生物相容的。
