Department of Breast Surgery, Zhejiang Cancer Hospital, Hangzhou, China.
Department of Breast Surgery, Zhejiang Cancer Hospital, Hangzhou, China.
Clin Breast Cancer. 2019 Feb;19(1):e172-e185. doi: 10.1016/j.clbc.2018.10.012. Epub 2018 Nov 3.
To determine the correlation between schizophrenia and breast cancer (BC).
We searched relevant articles indexed in the PubMed, Embase, and Cochrane Library databases; managed the data in Endnote X7 software; evaluated literature quality by Newcastle-Ottawa quality evaluation criteria; designed tables; and extracted relevant data. The main outcome measure was BC incidence. Effect values were risk ratio and 95% confidence intervals. We used Stata 13.1 software to perform the meta-analysis, choosing a corresponding combination model according to heterogeneity test results and carrying out subgroup analyses in order to better understand the stability of results through sensitivity analysis.
On the basis of 15 studies that assessed patients in different geographic regions, meta-analysis results showed that BC incidence between the exposure group (patients with schizophrenia) and the control group (nonschizophrenia population or general population) had statistical difference (risk ratio = 1.18; 95% confidence interval, 1.05, 1.32), thus showing that BC incidence in patients with schizophrenia is higher than in the nonschizophrenia or general population. Subgroup analysis indicated that gender and geographic region may be sources of the assessed studies' heterogeneity.
The incidence of schizophrenia is positively correlated with BC, and the incidence of BC in patients with schizophrenia is increased to a certain degree. Because of the effects of potential and publication bias, this conclusion needs more high-quality studies to increase the strength of evidence.
确定精神分裂症与乳腺癌（BC）之间的相关性。
我们检索了 PubMed、Embase 和 Cochrane Library 数据库中索引的相关文章；使用 Endnote X7 软件管理数据；采用 Newcastle-Ottawa 质量评价标准评价文献质量；设计表格并提取相关数据。主要观察指标为 BC 发病率。效应值为风险比及其 95%置信区间。我们采用 Stata 13.1 软件进行荟萃分析，根据异质性检验结果选择相应的组合模型，并进行亚组分析，通过敏感性分析更好地了解结果的稳定性。
基于评估不同地理区域患者的 15 项研究，荟萃分析结果显示，暴露组（精神分裂症患者）与对照组（非精神分裂症人群或一般人群）的 BC 发病率存在统计学差异（风险比=1.18；95%置信区间，1.05，1.32），表明精神分裂症患者的 BC 发病率高于非精神分裂症或一般人群。亚组分析表明，性别和地理区域可能是评估研究异质性的来源。
精神分裂症的发病率与 BC 呈正相关，精神分裂症患者的 BC 发病率在一定程度上增加。由于潜在和发表偏倚的影响，这一结论需要更多高质量的研究来增加证据强度。
